Research in Experimental Medicine

, Volume 179, Issue 1, pp 53–58 | Cite as

Effect of neurotensin on regional intestinal blood flow in the dog

  • I. Baća
  • U. Mittmann
  • G. E. Feurle
  • M. Haas
  • Th. Müller
Original Contributions


The effect of various doses of synthetic neurotensin on regional blood flow in different tissue layers of the stomach, small bowel, colon, pancreas, brain, kidneys, adrenal gland, and heart of six dogs was studied using an isotope microsphere technique. Infusion of high doses (20, 40 pmol/kg · min−1) of exogenous synthetic neurotensin caused an increase of blood flow in the “muscularis” of duodenum, jejunum, ileum, and colon. Neurotensin infused in a dose (2.5 pmol/kg · min−1) raising neurotensin plasma levels to concentrations comparable to those observed after a meal caused an increase of blood flow in the muscular layer in ileum. Our results suggest that one of the physiologic actions of neurotensin may be the regulation of blood flow in the muscular layer of the ileum.

Key words

Neurotensin infusion Neurotensin plasma levels Intestinal blood flow Microspheres 


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  1. 1.
    Anderson S, Chang D, Folkers K, Rosell S (1976) Inhibition of gastric acid secretion in dogs by neurotensin. Life Sci 19:367–370PubMedGoogle Scholar
  2. 2.
    Blackburn AM, Bloom SR, Long RG, Fletcher DR, Chritofides ND, Fitzpatrick ML, Baron JH (1980) Effect of neurotensin on gastric function in man. Lancet I:987–989Google Scholar
  3. 3.
    Bond JH, Prentiss RA, Levitt MD, Schoenborn K (1979) The effect of feeding on blood flow to the stomach, small bowel, and colon of the conscious dog. J Lab Clin Med 93:594–599PubMedGoogle Scholar
  4. 4.
    Brückner UB, Keller HE, Mittmann U, Wirth RH (1980) Influence of nifedipine on myocardial blood flow in dogs with acute coronary artery stenosis. Arzneim Forsch 30 (I) 5:780–784Google Scholar
  5. 5.
    Carraway R, Leeman SE (1973) The isolation of a new hypotensive peptide neurotensin from bovine hypothalamus. J Biol Chem 248:6854–6861PubMedGoogle Scholar
  6. 6.
    Carraway R, Leeman SE (1976) Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin. J Biol Chem 251:7053–7058PubMedGoogle Scholar
  7. 7.
    Chou CC, Grassmilk B (1978) Motility and blood flow distribution within the wall of the gastrointestinal tract. Am J Physiol 235 (1):H34–39PubMedGoogle Scholar
  8. 8.
    Dolas-Kitagbi J, Kitagbi P, Brazeau P, Freychet P (1979) Effect of neurotensin on insulin, glucagon, and somatostatin release from isolated pancreatic islets. Endocrinology 105:256–260PubMedGoogle Scholar
  9. 9.
    Granger DN, Richardson POJ, Kvietys PR, Mortilaro NA (1980) Intestinal blood flow. Gastroenterology 78:837–863PubMedGoogle Scholar
  10. 10.
    Helmstaedter V, Taugner CH, Feurle GE, Forssmann WG (1977) Localization of neurotensin immunoreactive cells in the small intestine of man and various mammals. Histochemistry 53:35–41PubMedGoogle Scholar
  11. 11.
    Nagai K, Frohman LA (1978) Neurotensin hyperglycemia: Evidence for histamine mediation and the assessment of a possible physiologic role. Diabetes 27:577–582PubMedGoogle Scholar
  12. 12.
    Osumi Y, Nagasaka Y, Wang LH Fu, Fujiwara N (1978) Inhibition of gastric acid secretion and mucosal blood flow induced by intraventricularly applied neurotensin in rats. Life Sci 23:2275–2280PubMedGoogle Scholar
  13. 13.
    Rosell SE, Burcher D, Chang D, Folkers K (1976) Cardiovascular and metabolic actions of neurotensin and (GlN4) neurotensin. Acta Physiol Scand 98:484–491PubMedGoogle Scholar
  14. 14.
    Sheperd AP, Granger HJ (1973) Autoregulatory escape in the gut: A system analysis. Gastroenterology 65:77–91PubMedGoogle Scholar
  15. 15.
    Sundler R, Häkansson R, Hammer RA, Alumest J, Carraway R, Leeman SE, Zimmermann EA (1977) Immunohistochemical localization of neurotensin in endocrine cells of the gut. Cell Tiss Res 178:313–321Google Scholar
  16. 16.
    Thor K, Rökaeus A, Kager L, Folkers K, Rosell S (1980) (Gln4)-neurotensin inhibits the interdigestive migrating motor complex in man. Regulatory Peptides [Suppl] 1:144Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • I. Baća
    • 1
  • U. Mittmann
    • 1
  • G. E. Feurle
    • 1
  • M. Haas
    • 1
  • Th. Müller
    • 1
  1. 1.Dept. of Surgery, Medical PolyclinicUniversity of HeidelbergHeidelberg 1Federal Republic of Germany

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