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Accommodation of skeletal muscle in rats under hypoxic conditions induced by tourniquet

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Summary

Resting membrane potential (RMP) and indexes of accommadation (IA) were obtained from the brachioradialis muscle in rats subjected to 2 or 5 h of bilateral hindlimb tourniquet. The results showed a highly significant increase in muscular IA with a return to the control values for the rats with 2 h of tourniquet, while the increased in the IA is maintained all the survival period in the rats with 5 h of tourniquet. The velocity of increasing of the IA bears a direct relationship to the outcome of the injury. A decrease in the RMP of the brachioradialis muscle and an increase in the extracellular K+ and H+ was also observed. The early differences in the behavior of the accommodation parameter allowed a clear differentiation of the rats which survived the tourniquet shock from those who finally died.

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Author information

Correspondence to L. Quevedo.

Additional information

Supported by grant no. DI 203302 from the University of Concepción, Chile

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Quevedo, L., Cárdenas, H. & Iturriaga, R. Accommodation of skeletal muscle in rats under hypoxic conditions induced by tourniquet. Res. Exp. Med. 182, 223–230 (1983). https://doi.org/10.1007/BF01851711

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Key words

  • Tourniquet
  • Shock
  • Electrophysiology
  • Electrodiagnosis