Research in Experimental Medicine

, Volume 173, Issue 3, pp 261–278 | Cite as

Metabolism of hydrogenated palatinose, an equimolar mixture ofα-D-glucopyranosido-1,6-sorbitol andα-D-glucopyranosido-1,6-mannitol

  • Uta Grupp
  • Günther Siebert
Article
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Accepted:

Summary

Hydrogenated palatinose, an equimolar mixture ofα-D-glucopyranosido-1,6-sorbitol andα-D-glucopyranosido-1,6-mannitol, was investigated as a potential oral sugar substitute in the following experiments in man and rat. 1. Enzymatic cleavage occured at slow rates by maltase (α-glucosidase) of jejunal mucosa, liver lysosomes and yeast. 2. Part of ingested hydrogenated palatinose arrived unsplit at the caecum of the rat and underwent fermentation there; excretions in feces and urine are neglegible in man and rat. 3. Growth and maintenance of rats demonstrated 20–40% diminished caloric utilisation of diets containing 34.5% hydrogenated palatinose whereas indirect calorimetry in man showed about 50% caloric deficit. 4. Blood sugar did not increase in man after oral doses up to 100g. 5. The capacity of the rat kidneys for excretion of hydrogenated palatinose and its constituents was high, symptoms of incompatibility were not observed.

Key words

Sugar substitute Caecum Glucosidosorbitol Glucosidomannitol Maltase Palatinose, hydrogenated 

Abbreviations

GPM

α-D-glucopyranosido-1,6-mannitol

GPS

α-D-glucopyranosido-1,6-sorbitol

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Uta Grupp
    • 1
  • Günther Siebert
    • 1
  1. 1.Department of Biological ChemistryUniversity of HohenheimStuttgart 70Federal Republic of Germany

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