Research in Experimental Medicine

, Volume 169, Issue 2, pp 169–174 | Cite as

Estimation of bone marrow injury through biopsies from whole-body irradiated monkeys (cebus apela)

  • Camilo Segreto
  • Antonio Matera
  • Frederic C. Ludwig


In the x-irradiated mammal, the ratio erythrocytes/nucleated cells is positively correlated with the radiation dose. In the present report, this correlation is used to estimate, by means of marrow biopsies, the radiation dose received by whole-body exposed monkeys.

Key words

Measurement of Radiation Injury Bone Marrow Damage Prognosis of Radiation Syndrome 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    LIEBOW, A.A., WARREN, SH., DE COURSEY, E.: Pathology of Atomic Bomb Casualties. Am. J. Path.XXV 853 (1949)Google Scholar
  2. 2.
    LUDWIG, F.C., KOHN, H.I.: Quantitative Studies on the Radiation Pathology of the Bone Marrow of Small Mammals. Rad. Res.17 579 (1962)Google Scholar
  3. 3.
    SEGRETO, C., LUDWIG, F.C.: Discrimination between Various Dose Levels in Whole-Body Irradiated Mice, by Counts of Bone Marrow Samples. Int. J. Appl. Rad. Isotopes23 545 (1972)Google Scholar
  4. 4.
    WELLINGTON, J.C., ELASHOFF, R.M., LUDWIG, F.C.: Bone Marrow Response to Acute Radiation Injury in RFM/U Mice after Whole- and Partial-Body Exposure to X-Rays. Int. J. Appl. Rad. Isotopes19 695 (1968)Google Scholar
  5. 5.
    KLAPPER, B.F.: Fungus Spores as Uniform Reference Particles for Use in Absolute Cell Counts. Appl. Microbiol.10 487 (1962)PubMedGoogle Scholar
  6. 6.
    LACASSAGNE, A., GRICOUROFF, G.: Actions des Radiations ionisantes sur l'organisme, p. 126. Paris: Masson 1956Google Scholar
  7. 7.
    HULSE, E.V.: Lymphocyte Depletion of the Blood and Bone Marrow of the Iŕradiated Rat: A Quantative Study. Brit. J. Haematol.5 278 (1959)Google Scholar
  8. 8.
    BOND, V.P., CRONKITE, E.P., FARR, R.S., HECHTER, H.H.: Hematologic Observations. From: Some Effects of Ionizing Radiation on Human Beings, pag. 43 F.F. Nav. Med. Res. Inst. Bethesda, Md., USAEC 1956Google Scholar
  9. 9.
    BURKHARDT, R.: Die Myelotomie, eine neue Methode zur kombinierten cytologisch-histologischen Knochenmarksbiopsie. Blut2 267 (1956)PubMedGoogle Scholar
  10. 10.
    BURKHARDT, R.: Technische Verbesserungen und Anwendungsbereich der Histo-Biopsie von Knochenmark und Knochen. Klin. Wschr.44 32 (1966)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Camilo Segreto
    • 1
  • Antonio Matera
  • Frederic C. Ludwig
    • 2
  1. 1.Laboratorio de RadiobiologiaEscola Paulista de Medicina, Caixa PostalSâo PauloBrasil
  2. 2.School of MedicineUniversity of CaliforniaIrvineUSA

Personalised recommendations