Childs Nervous System

, Volume 6, Issue 4, pp 190–193 | Cite as

Alteration of atrial natriuretic peptide receptors in the choroid plexus of rats with induced or congenital hydrocephalus

  • K. Mori
  • K. Tsutsumi
  • M. Kurihara
  • T. Kawaguchi
  • M. Niwa
Original Papers


Specific binding sites for atrial natriuretic peptide (ANP) in the choroid plexus of rats with induced or congenital hydrocephalus were examined using in vitro quantitative receptor autoradiographic methods. The number of125I-ANP binding sites in the choroid plexus of rats with kaolin-induced hydrocephalus was significantly higher as compared to findings in the control rats, whereas no differences in the binding affinity were observed 3 days and 3 weeks after the intracisternal injection of kaolin. Conversely, rats with congenital hydrocephalus (LEW-HYR and HTX rats) had a small number of binding sites for125I-ANP in the choroid plexus, as compared to findings in the control rats. These alterations may relate to the pathophysiology of hydrocephalus. The possibility that atrial natriuretic peptide may be involved in the regulation of cerebrospinal fluid production in the choroid plexus must be considered.

Key words

Atrial natriuretic peptide Receptor Choroid plexus Hydrocephalus 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. Mori
    • 1
  • K. Tsutsumi
    • 1
  • M. Kurihara
    • 1
  • T. Kawaguchi
    • 1
  • M. Niwa
    • 2
  1. 1.Department of NeurosurgeryNagasaki University School of MedicineNagasakiJapan
  2. 2.Department of Pharmacology 2Nagasaki University School of MedicineNagasakiJapan

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