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Frequency of D1S80 and HLA DQα alleles in a Chinese population

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Abstract

Allele frequency distributions for the D1S80 (MCT118) and HLA DQα loci were determined in a Chinese population sample using the polymerase chain reaction (PCR). A total of 25 alleles and 100 phenotypes were observed for D 1 S80. The frequency of allele 18 was higher than allele 24 only in this Chinese population when compared to other reported populations. A total of 6 alleles and 21 possible phenotypes were observed for HLA DQα. The power of discrimination was 0.97 and 0.93 for D1S80 and HLA DQα, respectively.

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References

  1. 1.

    Blake E, Mihalovich J, Higuchi R, Walsh PS, Erlich H (1992) Polymerase chain reaction (PCR) amplification and human leukocyte antigen (HLA) DQα oligonucleotide typing on biological evidence sample: casework experience. J Forensic Sci 37:700–726

  2. 2.

    Skowasch K, Wiegand P, Brinkmann B (1992) pMCT 118 (D1S80): a new allelic ladder and an improved electrophoretic separation lead to the demonstration of 28 alleles. Int J Legal Med 105:165–168

  3. 3.

    Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC (1991) Analysis of the VNTR locus D1S80 by the PCR followed by high resolution PAGE. Am J Hum Genet 48:137–144

  4. 4.

    Sullivan KM, Gill P, Lingard D, Lygo JE (1992) Characterization of HLA DQα for forensic purposes. Allele and genotypes in British Caucasian, Afro-Caribbean and Asian populations. Int J Legal Med 105:17–20

  5. 5.

    Sugiyama E, Honda K, Katsuyama Y, Uchiyama S, Tsuchikane A, Ota M, Fukushima H (1993) Allele frequency distribution of the D1S80 (pMCT118) locus polymorphism in the Japanese population by the polymerase chain reaction. Int J Legal Med 106:111–114

  6. 6.

    Huang NE, Chakraborty R, Budowle B (1994) D1S80 allele frequencies in a Chinese population. Int J Legal Med 107:118–120

  7. 7.

    Tamaki K, Yamamoto T, Uchihi R, Katsumata Y, Kondo K, Mizuno S, Kimura A, Sasazuki T (1991) Frequency of HLA DQA1 alleles in the Japanese population. Hum Hered 41:209–214

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Correspondence to Jian Tie.

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Tie, J., Oshida, S., Chiba, S. et al. Frequency of D1S80 and HLA DQα alleles in a Chinese population. Int J Leg Med 108, 170–171 (1995). https://doi.org/10.1007/BF01844833

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Key words

  • PCR
  • Population genetics
  • D1S80
  • HLA DQα
  • Chinese