An overview of glucocorticoid anti-inflammatory actions

  • R. P. Schleimer


Glucocorticoids (GC) exert a variety of important anti-inflammatory actions. We have studied their effects in allergic inflammation and believe that their antiallergic effects reflect their anti-inflammatory activities in general. These effects include inhibition of cytokine and other mediator secretion, inhibition of leucocyte priming in eosinophils and neutrophils, reduction of vascular permeability, inhibition of arachidonic acid metabolite and platelet activating factor (PAF) release, synergistic or permissive effects on responses to other mediators, such as catecholamines and other endogenous hormone-like molecules, and modulation of enzyme systems involved in inflammation. Glucocorticoid actions are thus multifaceted; this feature explains both their unequalled efficacy in inflammatory diseases and the difficulty in replacing them with other medications that have a uni-dimensional profile of action.

Key words

Glucocorticoid Anti-inflammatory allergy cytokine osinophil neutrophil leucocyte 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • R. P. Schleimer
    • 1
  1. 1.Johns Hopkins Asthma and Allergy CenterJohns Hopkins School of MedicineBaltimoreUSA

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