Immunogenetics

, Volume 7, Issue 1, pp 213–230

Immunoglobulin isoantigens (allotypes) in the mouse

V. Characterization of IgM allotypes
  • Samuel J. Black
  • James W. Goding
  • George A. Gutman
  • Leonard A. Herzenberg
  • Michael R. Loken
  • Barbara A. Osborne
  • Wessel van der Loo
  • Noel L. Warner
Original Investigations

Abstract

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjugates. Using both types of antibodies, we have defined a new constant-region locus for both secreted and membrane-bound μ chains. This locus,Ig-6, is closely linked to the previously described H-chain constant-region loci (Ig-1 throughIg-5) and is subject to allelic exclusion. We have identified three alleles and four antigenic specificities ofIg-6.

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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Samuel J. Black
    • 1
  • James W. Goding
    • 2
  • George A. Gutman
    • 2
  • Leonard A. Herzenberg
    • 1
  • Michael R. Loken
    • 1
  • Barbara A. Osborne
    • 1
  • Wessel van der Loo
    • 1
  • Noel L. Warner
    • 2
  1. 1.Department of GeneticsStanford University School of MedicineStanford
  2. 2.The Walter and Eliza Hall Institute of Medical ResearchVictoriaAustralia

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