Linkage between low-density lipoprotein and igk light-chain genes in rabbits
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Abstract
The rabbit geneLpq, which codes for a low-density serum lipoprotein2, is linked (34.6 ± 5.3 centimorgans) to the Ig kappa light-chain gene (Ab). There is no evidence thatLpq is linked to another gene,Prt, that was previously found to be linked to theAb gene. This suggests that the gene order for the three genes isPrt- Ab- Lpq.
Keywords
Linkage Group Light Chain Heterozygous Parent Individual Cross Light Chain Variable Region
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Abbreviations used in this paper
- Ig
immunoglobulin
- a
the heavy-chain variable-region geneAa
- b
the kappa light-chain geneAb
- q
the low-density serum lipoprotein geneLpq
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References
- Albers, J.J. and Dray, S.: Identification and genetic control of two rabbit low-density lipoprotein allotypes.Biochem. Genet. 2:25–35, 1968CrossRefPubMedGoogle Scholar
- Borresen, A.L., Berg, K., and Kindt, T.J.: A linkage study of rabbit serum high density lipoprotein (HDL) allotypes.J. Immunogenet. 4:81–95, 1977CrossRefPubMedGoogle Scholar
- Claflin, J.L.: Genetic marker in the variable region of kappa chains of mouse anti-phosphorylcholine antibodies.Eur. J. Immunol. 6:666–668, 1976CrossRefPubMedGoogle Scholar
- Dray, S., Young, G.O., and Gerald, L.: Immunochemical identification and genetics of rabbit γ-globulin allotypes.J. Immunol. 91:403–415, 1963PubMedGoogle Scholar
- Dray, S.: Genetics of gamma-globulin.In S.J. Groot (ed.):Genetics Today. Proceedings of the XI International Congress of Genetics. The Hague, The Netherlands, Sept. 1963, Vol. 2; pp. 165–180, Pergamon Press, Oxford, 1965Google Scholar
- Gedde-Dahl, T., Fagerhol, M., Cook, P. and Noades, J.: Autosomal linkage between theGm andPi loci in man.Ann. Hum. Genet. 35:393–399, 1972PubMedGoogle Scholar
- Gibson. D.: Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.J. Exp. Med. 144:298–303, 1976CrossRefPubMedGoogle Scholar
- Gilman-Sachs, A., Mage, R.G., Young, G.O., Alexander, C., and Dray, S.: Identification and genetic control of two rabbit immunoglobulin allotypes at a second light chain locus, thec locus.J. Immunol. 103:1159–1167, 1969PubMedGoogle Scholar
- Gottlieb, P.D.: Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.J. Exp. Med. 140:1432–1436, 1974CrossRefPubMedGoogle Scholar
- Mage, R., Lieberman, R., Potter, M., and Terry, W.D.: Immunoglobulin allotypes.In M. Sela (ed.):The Antigens; pp. 299–376, Academic Press, New York, 1973Google Scholar
- Mather, K.:The Measurement of Linkage in Heredity. London, Chapman and Hall, 1962Google Scholar
- Taylor, B., Bailey, D., Cherry, M., Rible, R., and Weigert, M.: Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in the mouse.Nature 256:644–646, 1975CrossRefPubMedGoogle Scholar
- Usher, D.C., Mayer, E.P., Dray, S., and Reiter, H.: Linkage between a gene for a serum protein and the gene for the Ig kappa light chain in rabbits.J. Immunol. 120:1832–1835, 1978PubMedGoogle Scholar
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