, Volume 7, Issue 1, pp 13–16

On the selective elimination of Y-bearing sperm

  • Susumu Ohno
  • Stephen S. Wachtel
Original Investigations


The potential use of antibodies that selectively recognize either X-bearing or Y-bearing sperm is self-evident. Thus our attention was directed to the fact that under optimal conditions, H-Y antibody lyses 50% of mouse spermatozoa. Accordingly, we asked whether expression of H-Y antigen is haploid in spermatozoa from XY male mice heterozygous for the autosomal dominantSxr gene, for if H-Y expression were haploid, H-Y antibody would be expected to kill 75% of spermatozoa derived from these XY,Sxr/- males. However, maximal lysis remained at the 50% level, which indicates that haploid expression of H-Y antigen and the potential immunoselection of Y-(or X-) bearing spermatozoa are unlikely.


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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Susumu Ohno
    • 1
  • Stephen S. Wachtel
    • 2
  1. 1.Department of BiologyCity of Hope National Medical CenterDuarte
  2. 2.Memorial Sloan-Kettering Cancer CenterNew York

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