Summary
Thirty rats with fecal peritonitis were treated by IP application of 50 mg human fibronectin. The lethality after 24 h could be reduced significantly in comparison with a control group of 30 untreated animals. This effect was similar to that of the IP application of 10 mg of mezlocillin. The combination of both substances had no effect on further reducing the lethality. After IP application, the plasma levels of human fibronectin were measured by laser nephelometry. They were high enough to explain the reduction in lethality as the effect of increasing opsonic and phagocytic activity of the RES.
Zusammenfassung
Die kotige Peritonitis der Ratte wurde bei 30 Tieren durch intraperitoneale Gabe von 50 mg humanem Fibronectin behandelt. Gegenüber einer Kontrollgruppe (n=30) wurde nach 24 h die Letalitat signifikant gesenkt. Der Therapieeffekt war dem einer Therapie mit 10 mg Mezlocillin intraperitoneal vergleichbar. Die Kombination beider Substanzen brachte keine weitere Senkung der Letalität. Die nach i.p. Gabe lasernephelometrisch gemessenen Plasmafibronectinspiegel reichen aus, umd die Wirksamkeit von Fibronectin als vermehrte Opsonierung and Steigerung der Phagocytoseleistung des RES zu deuten.
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Erttmann, M., Seifert, J. & Hamelmann, H. 313. Wirksamkeit von humanem Fibronectin bei intraperitonealer Gabe am Peritonitismodell der Ratte. Langenbecks Arch Chiv 366, 713 (1985). https://doi.org/10.1007/BF01836911
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DOI: https://doi.org/10.1007/BF01836911