Platelet-derived growth factor (PDGF) in plasma of breast cancer patients: Correlation with stage and rate of progression
- 153 Downloads
Plasma levels of platelet-derived growth factor (PDGF) were measured in 58 female patients with breast cancer and in 9 normal female control subjects by means of a specific radioimmunoassay. Levels in normal control subjects were all below the lower limits of detection by the assay (1.56 fmol/100 µl plasma). Two of 17 (12%) patients with stage 2 breast cancer had detectable plasma levels. Among patients with Stage 4 breast cancer 13/41 (32%) had significantly elevated levels (> 2 times the lower limit of sensitivity of the assay). Patients with elevated PDGF levels had a significantly greater degree of metastatic involvement and significantly shorter survival. Apart from being a marker of aggressive high bulk breast cancer, PDGF may be involved in the acceleration of growth of some metastatic breast tumors.
Key wordsplatelet-derived growth factor plasma concentrations immunoassay breast cancer prognosis tumor progression
Unable to display preview. Download preview PDF.
- 2.Antoniades HN, Owen AJ: Growth factors and regulation of cell growth. Ann Rev Med 33: 445–463, 1988Google Scholar
- 3.Ogaswara M, Subuska DA: A new serum-free method of measuring growth factor activities for human breast cancer cells in culture.In Vitro Cell Devel Biol 24: 911–920, 1988Google Scholar
- 16.Sainsbury JRC, Farndon JR, Needham GK, Malcolm AJ, Harris AL: Epidermal growth factor receptor as a predictor of early recurrence and death from breast cancer. Lancet i: 1398–1402, 1987Google Scholar
- 18.Patterson AH, Lees AW, Jamil N, Dietrich KD, Huson J, Fourney RM, Salmon DJ, Patterson MC, Danyluk J: Comparison of Her-2/neu oncogene amplification with other prognostic factors in node negative patients with breast cancer. Proc ASCO 8: 99, 1989Google Scholar
- 25.Yarden Y, Escobedo JA, Kuang W-J, Yang-Feng TL, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U, Freed VA, Ullrich A, Williams L: Structure of the receptor for platelet-derived growth factor helps to define a family of closely related receptors. Nature 323: 226–232, 1986PubMedGoogle Scholar
- 28.Bernabei PA, Arcangeli A, Casini M, Grossi A, Padovani R, Rossi Ferrini P: Platelet-derived growth factor(s) mitogenic activity in patients with myeloproliferative disease. Brit J Haematol 63: 353–357, 1986Google Scholar
- 37.Golombick T, Bezwoda WR: Long term growth of a new ovarian cancer cell line UWOV2 (pf) in tissue culture in the absence of exogenous serum factors, proteins transferrin and insulin: a potential model for autonomous growth and tumor progression. Eur J Cell Biol (in press)Google Scholar