Breast Cancer Research and Treatment

, Volume 24, Issue 1, pp 51–59 | Cite as

A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors

  • Ikuko Kato
  • Shigeto Miura
  • Fijio Kasumi
  • Takuji Iwase
  • Hideya Tashiro
  • Yoshihiro Fujita
  • Hiroki Koyama
  • Tadashi Ikeda
  • Kiyoshi Fujiwara
  • Keiichi Saotome
  • Kazuaki Asaishi
  • Rikiya Abe
  • Mitsuhiro Nihei
  • Tsunehiro Ishida
  • Takao Yokoe
  • Hiroshi Yamamoto
  • Motoi Murata


To study the effects of family history and reproductive, anthropometric, and dietary factors on the risk of breast cancer among low risk populations, we conducted a hospital-based case-control study involving 908 patients with breast cancer and their matched controls, in Japan. A positive family history of breast cancer significantly increased the risk of breast cancer (odds ratio = 1.52, 95% confidence interval: 1.14–2.03). The risk further increased with increasing number of family members affected. Obesity, single marital status, fewer births, a late childbirth, and less consumption of green-yellow vegetables and dairy products were also associated with an increased risk of breast cancer. These associations were independent in multivariate analyses. There was no increase in risk associated with consumption of high fat foods. When analyzed by menopausal status, the association with family history of breast cancer, especially in the first degree of relatives, was more evident for premenopausal breast cancer. The associations with obesity and lower consumption of dairy products were more pronounced for postmenopausal breast cancer, while those with lower parity and single marital status were stronger for premenopausal breast cancer.

Key words

breast cancer family history reproductive history diet obesity 


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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Ikuko Kato
    • 1
  • Shigeto Miura
    • 2
  • Fijio Kasumi
    • 3
  • Takuji Iwase
    • 3
  • Hideya Tashiro
    • 4
  • Yoshihiro Fujita
    • 5
  • Hiroki Koyama
    • 7
  • Tadashi Ikeda
    • 8
  • Kiyoshi Fujiwara
    • 8
  • Keiichi Saotome
    • 8
  • Kazuaki Asaishi
    • 9
  • Rikiya Abe
    • 10
  • Mitsuhiro Nihei
    • 10
  • Tsunehiro Ishida
    • 11
  • Takao Yokoe
    • 11
  • Hiroshi Yamamoto
    • 12
  • Motoi Murata
    • 6
  1. 1.Division of EpidemiologyAichi Cancer CenterNagoya
  2. 2.Department of Breast SurgeryAichi Cancer CenterNagoya
  3. 3.Department of SurgeryCancer Institute HospitalTokyo
  4. 4.Department of Breast SurgeryNational Kyushu Cancer CenterFukuoka
  5. 5.Division of SurgeryChiba Cancer CenterChiba
  6. 6.Department of EpidemiologyChiba Cancer CenterChiba
  7. 7.Third Department of SurgeryThe Center for Adult DiseasesOsaka
  8. 8.Department of Surgery, School of MedicineKeio UniversityTokyo
  9. 9.Department of Surgery, Section 1Sapporo Medical College & HospitalSapporo
  10. 10.Second Department of SurgeryFukushima Medical CollegeFukushima
  11. 11.Second Department of Surgery, School of MedicineGunma UniversityMaebashi
  12. 12.Department of Surgical OncologyNational Cancer CenterTokyoJapan

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