Clinical Autonomic Research

, Volume 2, Issue 5, pp 303–307 | Cite as

Elevation of plasma atrial natriuretic peptide occurs during adrenaline infusion in hypertensive but not normotensive subjects

  • Terry J. Tunny
  • Richard D. Gordon
  • Anthony W. Bachmann
  • Shelley A. Klemm
Research Paper
Received:
Accepted:
  • 15 Downloads

Abstract

The levels of plasma atrial natriuretic peptide in response to graded adrenaline infusion were determined in six patients with essential hypertension and six healthy normotensive subjects (controls). Basal plasma adrenaline concentration was similar in both groups and rose progressively and to a similar level during adrenaline infusion. Plasma noradrenaline rose in both groups and to the same extent during the 26 and 39 ng/kg/min adrenaline infusion rates. Basal plasma atrial natriuretic peptide levels were higher in the hypertensives than in the controls. Graded adrenaline infusion had no effect on atrial natriuretic peptide levels in the controls but significantly raised atrial natriuretic peptide levels in the hypertensives. Systolic blood pressure rose progressively during adrenaline infusion at a lower infusion rate in the hypertensives than in the controls. Similarly, while heart rate rose during adrenaline infusion in both groups, there was a greater rise in the hypertensives. The increased cardiovascular. responsiveness to adrenaline infusion in patients with essential hypertension may explain why plasma atrial natriuretic peptide levels rose only in this group and not the normotensive subjects.

Key words

Atrial natriuretic peptide Adrenaline Hypertension Normal subjects Renin Aldosterone Human 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Majewski H, Tung LH, Rand MJ. Adrenaline activation of pre-junctionalβ-adrenoceptors and hypertension.J Cardiovasc Pharmacol 1982;4: 99–106.PubMedGoogle Scholar
  2. 2.
    Musgrave IF, Bachmann AW, Gordon RD. Increased plasma noradrenaline during adrenaline infusion in man.J Hypertension 1984;2 (suppl 3): 135–137.Google Scholar
  3. 3.
    Brown MJ, Macquin I. Is adrenaline the cause of essential hypertension?Lancet 1981;ii: 1079–1082.Google Scholar
  4. 4.
    Blankestijn PJ, Man in't Veld AJ, Tulen J, van den Meiracker AH, Boomsma F, Moleman P, Ritesma van Eck HJ, Derkx FHM, Mulder P, Lamberts SJ, Schalekamp MADH. Support for adrenalinehypertension hypothesis: 18 hour pressor effect after 6 hours adrenaline infusion.Lancet 1988;ii: 1386–1389.Google Scholar
  5. 5.
    Freeman ZS. Stress and hypertension—a critical review.Med J of Australia 1990;153: 621–625.Google Scholar
  6. 6.
    Goldstein DS, Macarty R, Polinsky RJ, Kopin IJ. Relationship between plasma norepinephrine and sympathetic neural activity.Hypertension 1983;5: 552–559.PubMedGoogle Scholar
  7. 7.
    de Champlain J, Cleroux J, Lebeau R, Gonzalez M, Nadeau R. Abnormalities in the regulation of sympathetic activity in human hypertension.Clin Invest Med 1987;10: 573–580.PubMedGoogle Scholar
  8. 8.
    Esler M, Lambert G, Jennings G. Increased regional sympathetic nervous activity in human hypertension: causes and consequences.J Hypertension 1990;8 (suppl 7): S53-S57.Google Scholar
  9. 9.
    Dietz JR. Release of natriuretic factor from rat heart-lung preparation by atrial distension.Am J Physiol 1984;247: R1093-R1096.PubMedGoogle Scholar
  10. 10.
    Ledsome JR, Wilson N, Courneya CA, Rankin AJ. Release of atrial natriuretric peptide by atrial distension.Can J Physiol Pharmacol 1985;63: 739–742.PubMedGoogle Scholar
  11. 11.
    Sanfield JA, Shenker Y, Grekin RJ, Rosen SG. Epinephrine increases plasma immunoreactive atrial natriuretic hormone levels in humans.Am J Physiol 1987;252: E740-E745.PubMedGoogle Scholar
  12. 12.
    Tunny TJ, Bachmann AW, Gordon RD. Response of atrial natriuretic peptide to adrenaline and noradrenaline infusion in man.Clin Exp Pharmacol Physiol 1988;15: 299–303.PubMedGoogle Scholar
  13. 13.
    Uehlinger DE, Weidmann P, Gnaedinger MP, Shaw S, Lang RE. Depressor effects and release of atrial natriuretic peptide during norepinephrine or angiotensin II infusion in man.J Clin Endocrinol Metab 1986;63: 669–674.PubMedGoogle Scholar
  14. 14.
    Tunny TJ, Klemm SA, Gordon RD. Effects of angiotensin and noradrenaline on atrial natriuretic peptide levels in man.Clin Exp Pharmacol Physiol 1987;14: 221–225.PubMedGoogle Scholar
  15. 15.
    Anderson GH, Miller M. Angiotensin II infusion increases plasma atrial natriuretic hormone in normal subjects, but nifedipine blocks this increase. In: Brenner BM, Laragh JH, eds.Biologically active atrial peptides. New York: Raven Press, 1987: 439–442.Google Scholar
  16. 16.
    Klemm SA, Tunny TJ, Gordon RD. Atrial natriuretic peptide levels during angiotensin infusion and indomethacin administration are consistent with angiotensin-mediated regulation in man.J Hypertension 1987;5 (suppl 5): S75-S78.Google Scholar
  17. 17.
    Winquist RJ, Scott AL, Vlasuk GP. Enhanced release of atrial natriuretic factor by endothelin in atria from hypertensive rats.Hypertension 1989;14: 111–114.PubMedGoogle Scholar
  18. 18.
    Gardner DG, Schultz HD. Prostaglandins regulate the synthesis and secretion of the atrial natriuretic peptide.J Clin Invest 1990;86: 52–59.PubMedGoogle Scholar
  19. 19.
    Richards AM, McDonald D, Fitzpatrick MA, Nicholls MG, Espiner EA, Ikram H, Jans S, Grant S, Yandle T. Atrial natriuretic hormone has biological effects in man at physiological plasma concentrations.J Clin Endocrinol Metab 1988;67: 1134–1139.PubMedGoogle Scholar
  20. 20.
    Tunny TJ, Higgins BA, Gordon RD. Plasma levels of atrial natriuretic peptide in man in primary aldosteronism, in Gordon's syndrome and in bartter's syndrome.Clin Exp Pharmacol Physiol 1986;13: 341–345.PubMedGoogle Scholar
  21. 21.
    Saar N, Bachmann AW, Gordon RD. Radioenzymic measurement of norepinephrine, epinephrine and dopamine: stability, enzymic activity, and sensitivity.Clin Chem 1981;27: 626–628.PubMedGoogle Scholar
  22. 22.
    Haber E, Koerner T, Page LB, Kliman B, Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.J Clin Endocrinol Metab 1969;29: 1349–1355.PubMedGoogle Scholar
  23. 23.
    Morrow LA, Morganroth GS, Hill TJ, Sanfield JA, Rosen SG, Grekin RJ, Halter JB. Atrial natriuretic factor in the elderly: diminished response to epinephrine.Am J Physiol 1989;257: E866-E870.PubMedGoogle Scholar
  24. 24.
    Garcia R, Lahance D, Thibault G, Cantin M, Gutowska J. Mechanisms of release of atrial natriuretic factor.Biochem Biophys Res Commun 1986;136: 510–520.PubMedGoogle Scholar
  25. 25.
    McKnight JA, Roberts G, Sheridan B, Atkinson B. Relationship between basal and sodium-stimulated plasma atrial natriuretic factor, age, sex and blood pressure in normal man.J Human Hypertension 1989;3: 157–163.Google Scholar
  26. 26.
    Ruskoaho H, Lang RE, Toth M, Ganten D, Unger T. Release and regulation of atrial natriuretic peptide.Eur Heart J 1987;8 (suppl B): 99–109.Google Scholar
  27. 27.
    Wong NML, Wong EFC, Au GH, Hu DCK. Effect ofα- andβ-adrenergic stimulation on atrial natriuretic peptide releasein vitro.Am J Physiol 1988;255: E260-E264.PubMedGoogle Scholar
  28. 28.
    Schiffrin EL, Gutkowska J, Kuchel O, Cantin M, Genest J. Plasma concentration of atrial natriuretic factor in a patient with atrial tachycardia.N Engl J Med 1985;312: 1196–1197.PubMedGoogle Scholar
  29. 29.
    Tikkanen I, Fyhrquist F, Metsarinne K, Leidenius R. Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers.Lancet 1985;ii: 66–69.Google Scholar
  30. 30.
    Nilsson G, Pettersson A, Hedner J, Hedner T. Increased plasma levels of atrial natriuretic peptide (ANP) in patients with paroxysmal supraventricular tachyarrhythmias.Acta Med Scand 1987;221: 15–21.PubMedGoogle Scholar
  31. 31.
    Burnett JC, Osborn MJ, Hammill SC, Heublein DM. The role of frequency of atrial contraction versus atrial pressure in atrial natriuretic peptide release.J Clin Endocrinol Metab 1989;69: 881–884.PubMedGoogle Scholar
  32. 32.
    Sagnella GA, Markandu ND, Shore AC, Macgregor GA. Raised circulating levels of atrial natriuretic peptides in essential hypertension.Lancet 1986;i: 179–181.Google Scholar
  33. 33.
    Sugawara A, Nakao K, Kono T, Morii N, Yamada T, Itoh H, Shiono S, Saito Y, Mukoyama M, Arai H, Imura H. Atrial natriuretic factor in essential hypertension and adrenal disorders.Hypertension 1988;11 (suppl I): 1212–1216.Google Scholar
  34. 34.
    Currie MG, Newman WH. Evidence forα-1 adrenergic receptor regulation of atriopeptin release from the isolated rat heart.Biochem Biophys Res Commun 1986;137: 94–100.PubMedGoogle Scholar

Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • Terry J. Tunny
    • 1
  • Richard D. Gordon
    • 1
  • Anthony W. Bachmann
    • 1
  • Shelley A. Klemm
    • 1
  1. 1.Endocrine-Hypertension Research UnitGreenslopes HospitalBrisbaneAustralia

Personalised recommendations