Gender related differences in the cardiovascular responses to upright tilt in normal subjects
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The heart rate and blood pressure responses to head-up tilt of 80 degrees was studied in 20 normal men and 21 normal women aged 20–50 years (mean age 31.1 ± 7.1 years). The heart rate increase in females during tilt was 73% that of males, whereas the increase in diastolic pressure during tilt was 29% of males. Expressed in relation to values obtained supine, heart rate increases on average 30.3% in men as compared to 21.5% in women whereas diastolic pressure increases by 15.2% in men as compared to an increase of only 4.3% in women. The data indicates that the cardiovascular response of normal females to upright tilt differs significantly from that of normal males. This attenuated responsiveness to ortho-stasis in women relative to men may predispose women to postural insufficiency and may account for the predominance of symptomatic women with clinically mild dysautonomia.
Key wordsUpright tilt Blood pressure Heart rate Male Female
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- 2.Streeten DHP, Kerr LP, Kerr CB, Prior JC, Dalakos TG. Hyperbradykininism: a new orthostatic syndrome.Lancet 1972;ii: 1048–1053.Google Scholar
- 3.Polinsky RJ, Kopin IJ, Ebert MH, Weise V. Pharmacologic distinction of different orthostatic hypotension syndromes.Neurology 1981;31: 1–7.Google Scholar
- 6.Schondorf R, Low PA. Idiopathic postural tachycardia syndrome.Ann Neurol 1990;28: 271.Google Scholar
- 14.Shvartz E, Meyerstein N. Tilt tolerance of young men and young women.Aerospace Med 1970;41: 253–255.Google Scholar
- 17.Schondorf R, Low PA. Comparison of the cardiovascular response to tilt of normal male and female subjects.Neurology 1991;41 (suppl 1): 354.Google Scholar
- 19.Pagani M, Lombardi F, Guzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, Turiel M, Baselli G, Serutti S, Malliani A. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.Circ Res 1986;59: 178–193.PubMedGoogle Scholar
- 20.Johansson SR, Hjalmarson A. Age and sex differences in cardiovascular reactivity to adrenergic agonists, mental stress and isometric exercise in normal subjects.Scand J Lab Invest 1988;48: 183–191.Google Scholar