Parkinson's disease and weight loss: A study with anthropometric and nutritional assessment
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In order to investigate a putative weight loss in patients with Parkinson's disease, an anthropometric and biochemical study was undertaken. We compared body weight and indexes of fat [body mass index (BMI), tricipital skinfold] and lean [midarm muscle area (MMA), calf circumference] mass in men and women suffering from idiopathic Parkinson's disease with normal controls. We found that women suffering from Parkinson's disease exhibited a significant weight loss (−8.5%) and decreased calf circumference when compared with controls. A decrease (−4.3%) in total body weight was also found in men with Parkinson's disease but the difference did not reach the level of significance. Protein biochemical markers of nutritional status (albumin, prealbumin, retinol binding protein, transferrin) were normal in Parkinson's disease patients. The present study demonstrates the occurrence of weight loss in a large population of patients with Parkinson's disease. The putative mechanisms involved in the weight loss are discussed.
Key wordsParkinson's disease Weight loss Anthropometric assessment
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- 1.Korczyn AD. Autonomic nervous system dysfunction in Parkinson's disease. In: Calne DB, Comi G, Grippa D, Horowski R, Trabucchi M, eds.Parkinsonism and Aging. New York: Raven Press, 1989; 211–219.Google Scholar
- 3.Senarath Yapa RS, Playfer JR, Lye M. Anthropometric and nutritional assessment of elderly patients with Parkinson's disease.J Clin Exp Gerontol 1989;11: 155–164.Google Scholar
- 4.Levi S, Cox M, Lugon M, Hodkinson M, Tomkins A. Increased energy expenditure in Parkinson's disease.Br Med J 1990;301: 1256–1257.Google Scholar
- 6.Van der Linden C, Jankovic J, Jansson B. Lateral hypothalamic dysfunction in Parkinson's disease.Ann Neurol 1985;18: 137–138 (abstract).Google Scholar
- 7.Fahn S, Elton RL, Members of the UPDRS Development Committee. Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Calne D, Goldstein M, eds.Recent Developments in Parkinson's Disease. Florham Park, NJ: Macmillan Healthcare Information, 1987; 153–163.Google Scholar
- 9.Chumlea WC, Vellas BJ, Roche AF, Guo S, Steinbaugh M. Particularités et intérêt des mesures anthropométriques du statut nutritionnel des personnes âgées.Age and Nutrition 1990;1: 7–12.Google Scholar
- 10.Apfelbaum M, Perlemuter L, Nillus P, Forrat C, Begon M.Dictionnaire pratique de diététique et de nutrition. Paris: Masson, 1991.Google Scholar
- 11.Lellouch J, Lazar P. Méthodes statistiques en expérimentation biologique. Paris: Flammarion Médecine Sciences, 1974; 99–101.Google Scholar
- 12.Rosalind, Gibson.Principles of Nutritional Assessment. Oxford: Oxford University Press, 1990; 608.Google Scholar
- 14.Leibowitz SF. Brain monoamine projections and receptors systems in relation to food intake, diet preference, meal patterns and body weight. In: Brown GM, ed.Neuroendocrinology and Psychiatric Disorders. New York: Raven Press, 1984; 383–399.Google Scholar
- 15.Rabey JM, Streifler M, Treves T, Korczyn AD. A long-term comparative study of lisuride and levodopa in Parkinson's disease. In: Calne DB, Comi G, Grippa D, Horowski R, Trabucchi M, eds.Parkinsonism and Ageing. New York: Raven Press, 1989; 261–267.Google Scholar