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L-carnitine and glycine therapy in isovaleric acidaemia

  • R. A. Chalmers
  • C. de Sousa
  • B. M. Tracey
  • T. E. Stacey
  • C. Weaver
  • D. Bradley
Short Communication

Keywords

Public Health Internal Medicine Glycine Metabolic Disease Isovaleric Acidaemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Chalmers, R. A., Roe, C. R., Tracey, B. M., Stacey, T., Hoppel, C. L. and Millington, D. S. Secondary carnitine insufficiency in disorders of organic acid metabolism: modulation of acyl CoA/CoA ratios byl-carnitinein vivo.Biochem. Soc. Trans. 11 (1983) 724–725Google Scholar
  2. Dubiel, B., Dabrowski, C., Wetts, R. and Tanaka, K. Complementation studies of isovaleric acidemia and glutaric aciduria type II using cultured skin fibroblasts.J. Clin. Invest. 72 (1983) 1543–1552PubMedGoogle Scholar
  3. Kreiger, I. and Tanaka, K. Therapeutic effects of glycine in isovaleric acidemia.Pediatr. Res. 10 (1976) 25–29PubMedGoogle Scholar
  4. Roe, C. R., Hoppel, C. L., Stacey, T. E., Chalmers, R. A., Tracey, B. M. and Millington, D. S. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups.Arch. Dis. Child. 58 (1983) 916–920PubMedGoogle Scholar
  5. Truscott, R. J. W., Malegan, D., McCairns, E., Burke, D., Hicks, L., Sims, P., Halpern, B., Tanaka, K., Sweetman, L., Nyhan, W. L., Hammond, J., Bumack, C., Haan, E. A. and Danks, D. M. New metabolites in isovaleric acidemia.Clin. Chim. Acta 110 (1981) 187–203PubMedGoogle Scholar
  6. Wysocki, S. J., French, N. P. and Grauaug, A. Organic aciduria associated with isovaleric aciduria.Clin. Chem. 29 (1983) 1002–1003PubMedGoogle Scholar
  7. Yudkoff, M., Cohn, R. M., Puschak, R., Rothman, R. and Segal, S. Glycine therapy in isovaleric acidemia.J. Pediatr. 92 (1978) 813–817PubMedGoogle Scholar

Copyright information

© SSIEM and MTP Press Limited 1985

Authors and Affiliations

  • R. A. Chalmers
    • 1
  • C. de Sousa
    • 1
  • B. M. Tracey
    • 1
  • T. E. Stacey
    • 1
  • C. Weaver
    • 2
  • D. Bradley
    • 2
  1. 1.Paediatric Research GroupMRC Clinical Research CentreHarrowUK
  2. 2.Department of Child Health and MedicineUniversity Hospital of WalesCardiffUK

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