Clinical & Experimental Metastasis

, Volume 8, Issue 4, pp 299–304 | Cite as

Neoplastic invasion in experimental carcinoma of the colon: abnormal differentiation and release of mucus

  • I. Carr
  • K. Orr


Carcinomas of the colon were induced in F344 rats with dimethylhydrazine (20 mg/kg for 12 weeks). The invasive edges of the lesions were examined with the electron microscope. As in human colorectal cancer, the invasive edges show neoplastic cells with abnormal differentiation of apical cytoplasmic rootlets and processes at the basal or invasive edge of the cell, ‘apical reversal’. Mucous carcinoma cells release material into the interstitial connective tissue matrix. The features may contribute to the complex phenomenon of neoplastic invasion.


Public Health Carcinoma Electron Microscope Carcinoma Cell Colorectal Cancer 
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Copyright information

© Taylor & Francis Ltd. 1990

Authors and Affiliations

  • I. Carr
    • 1
  • K. Orr
    • 1
  1. 1.Departments of Pathology and ImmunologyUniversity of Manitoba and St Boniface General HospitalWinnipegCanada

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