New insights on the comma-less theory

  • Enrique Merino
  • Paulina Balbás
  • Francisco Bolivar
Article

Abstract

The comma-less hypothesis represents a theoretical effort to describe one of the steps in the early evolution of the translation apparatus. This hypothesis emphasizes the advantages that a RNY coding pattern would have provided in a primitive RNA adaptor-catalyst system. This theory has been debated for years, both in conceptual and statistical terms, and no consensus about its validity has been ascertained. In this work, a statistical model refuting this theory was reconsidered. This new approach eliminates the bias due to the absence of stop codons in the open reading frame, and to the amino acid composition of bacterial genes. The results obtained support the biological significance of the RNY coding pattern.

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References

  1. Crick, F. H. C., Griffith, J. S., and Orgel, L. E.: 1957,Proc. Natl. Acad. Sci. U.S.A. 43, 416–421.Google Scholar
  2. Crick, F. H. C., Brenner, S., Klug, A., Pieczenik, G.: 1976,Origins Life 7, 389–397.Google Scholar
  3. Eigen, M. and Shuster, P.: 1978,Naturwissenschaften 65, 341–369.Google Scholar
  4. Shepherd, J. C. W.: 1981,Proc. Natl. Acad. Sci. U.S.A. 78, 1596–1600.PubMedGoogle Scholar
  5. Shepherd, J. C. W.: 1984,Cold Spring Harbor Symp. Quant. Biol. 47, 1099–1108.Google Scholar
  6. Shepherd, J. C. W.: 1990,Meth. Enzymol. 183, 180–192.PubMedGoogle Scholar
  7. Staden, R.: 1984,Nucl. Acids. Res. 12, 551–567.PubMedGoogle Scholar
  8. Wong, J. T.-F.:Trends Biochem. Sci. 6, 33–35.Google Scholar
  9. Wong, J. T.-F. and Cedergren, R.: 1986,Eur. J. Biochem. 159, 175–180.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Enrique Merino
    • 1
  • Paulina Balbás
    • 1
  • Francisco Bolivar
    • 1
  1. 1.Department of Molecular Biology, Instituto de BiotecnologíaUniversidad Nacional Autónoma de MéxicoMexico

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