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Origins of life: An operational definition

  • Gail Raney Fleischaker
Article

Abstract

Two very different models are used for the scientific study of life's origins: in the Troland-Muller model, life is molecular and its defining characteristic is gene function; in the Oparin-Haldane model, life is cellular and its defining characteristic is metabolic function. While each of these models implicitly defines the living, neither provides criteria by which theemergence of life could be recognized in the laboratory.

Anoperational definition of the living makes explicit the system logic of metabolic self-production: (1) that whatever form it may take, life is a function of its biochemical processes; (2) that no single biochemical process has integrity apart from an entire network of processes; (3) that a network of processes can have continuity only by being enclosed within a boundary structure, i.e., by the selective partition of a microenvironment as a domain for the bioenergetic-biosynthetic network; and (4) that life is a single phenomenon, distinct in its continuity of capture and storage of energy in such networks, driving the processes that produce its material constituents.

This paper presentsautopoiesis as life-defining and discusses the utility of its criteria in our search for the origins of life on Earth. Enactment of the autopoietic criteria would result in aminimal cell and would demonstrate the experimental recapitulation of life's Archaean origins.

Keywords

Organic Chemistry Geochemistry Gene Function Scientific Study Biochemical Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Borowska, Z. and Mauzerall, D.: 1988,Proc. Nat. Acad. Sci. U.S.A. 85, 6577–6580.Google Scholar
  2. Bogomolni, R. A. and Stoeckenius, W.: 1974,J. Supramolecular Structure 2, 775–780.Google Scholar
  3. Deamer, D. W. and Barchfeld, G.: 1982,J. of Molecular Evolution 18, 203–206.Google Scholar
  4. Fleischaker, G. R.: 1988,BioSystems 22, 37–49.PubMedGoogle Scholar
  5. Haldane, J. B. S.: 1929,The Rationalist Annual 3, 3–10.Google Scholar
  6. Kamminga, H.: 1988,Origins of Life and Evolution of the Biosphere 18, 1–11.Google Scholar
  7. Maloney, P. C. and Wilson, T. H.: 1985,BioScience 35, 43–48.Google Scholar
  8. Maturana, H. R. and Varela, F. J.: 1973a,De Máquinas y Seres Vivos — Una Teoría sobre la organización biológica [© 1972], Editorial Universitaria S.A., Santiago.Google Scholar
  9. Maturana, H. R., and Varela, F. J.: 1973b, inAutopoiesis and Cognition — The Realization of the Living [© 1980], D. Reidel, Dordrecht, Holland, pp. 73–141.Google Scholar
  10. Morowitz, H. J.: 1981,BioSystems 14, 41–47.PubMedGoogle Scholar
  11. Morowitz, H. J., Heinz, B., and Deamer, D. W.: 1988,Origins of Life and Evolution of the Biosphere 18, 281–287.PubMedGoogle Scholar
  12. Muller, H. J.: 1929,Proc. Int. Congr. of Plant Sciences 1, 897–921.Google Scholar
  13. Oparin, A. I.: 1924, in J. D. Bernal,The Origin of Life [© 1967], Weidenfeld and Nicolson, London, pp. 199–234.Google Scholar
  14. Oparin, A. I.: 1938,The Origin of Life, 1st ed., transl. S. Morgulis, Macmillan, New York.Google Scholar
  15. Oesterhelt, D. and Stoeckenius, W.: 1973,Proc. Nat. Acad. Sci. U.S.A. 70, 2853–2857.Google Scholar
  16. Sagan, D. and Margulis, L.: 1988,Garden of Microbial Delights — A Practical Guide to the Subvisible World, Harcourt Brace Jovanovich, Boston.Google Scholar
  17. Schrödinger, E.: 1945,What Is Life?, The University Press, Cambridge.Google Scholar
  18. Swenson, R.: 1989,Systems Research 6 (No. 3), 187–197.Google Scholar
  19. Tanford, C.: 1978,Science 200, 1012–1018.PubMedGoogle Scholar
  20. Troland, L. T.: 1917,The American Naturalist 51, 321–350.Google Scholar
  21. Varela, F. J., Maturana, H. R., and Uribe, R.: 1974,BioSystems 5, 187–196.Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Gail Raney Fleischaker
    • 1
  1. 1.Laboratories of the Museum of Comparative ZoologyHarvard UniversityCambridgeUSA

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