Origins of life and evolution of the biosphere

, Volume 17, Issue 2, pp 155–169

How many genes to start with? A computer simulation about the origin of life

  • Ursula Niesert


A geneticist's view on the origin of life would focus on individual nucleic acid molecules rather than on their concentrations, on stochastics rather than on differential equations.

The ‘package model’ envisages primordial compartments that contain ensembles of primordial genes. These are replicated independently from each other. During package fission they are distributed to two daughter packages. Packages with a complete ensemble of genes can continue to propagate. However, mutations as well as the stochastic nature of replication and package fission occasionally cause arising packages to miss genes from the ensemble, thus resulting in the death of those packages.

A computer simulation, considering the complementarity of RNA as well as abortive termination of replication, yielded results that are similar to those of a preliminary simulation irrespective of these parameters: the results suggest that life could not have started with more than 3 genes, or else the primordial replicase would have to achieve at least a reduction of the replicational error rate by a factor of 13 and a reduction of undue chain termination by a factor of 10 to 25.


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  1. Bresch, C., Niesert, U., and Harnasch, D.: 1980,J. Theoret. Biol. 85 399.Google Scholar
  2. Bridson, P. K. and Orgel, L. E.: 1980,J. Mol. Biol. 144 567.PubMedGoogle Scholar
  3. Crick, F. H. C., Brenner, S., Klug, A., and Pieczenik, G.: 1976,Origins of Life 7 389.PubMedGoogle Scholar
  4. Eigen, M.: 1971,Naturwissenschaften 58 465.PubMedGoogle Scholar
  5. Eigen, M. and Schuster, P.: 1977,Naturwissenschaften 64 541.PubMedGoogle Scholar
  6. Eigen, M. and Schuster, P.: 1978a,Naturwissenschaften 65 7.Google Scholar
  7. Eigen, M. and Schuster, P.: 1978b,Naturwissenschaften 65 341.Google Scholar
  8. Eigen, M. and Schuster, P.: 1982,J. Mol. Evol. 19 47.PubMedGoogle Scholar
  9. Eigen, M., Gardiner, W. C., and Schuster, P.: 1980,J. Theoret. Biol. 85 406.Google Scholar
  10. Hopfield, J. J.: 1978,Proc. Nat. Acad. Sci. USA 75 4334.PubMedGoogle Scholar
  11. Inoue, T. and Orgel, L. E.: 1983,Science 219 859.PubMedGoogle Scholar
  12. Niesert, U., Harnasch, D., and Bresch, C.: 1981,J. Mol. Evol. 17 348.PubMedGoogle Scholar
  13. Niesert, U.: 1984, Dissertation, University Freiburg.Google Scholar

Copyright information

© D. Reidel Publishing Company 1987

Authors and Affiliations

  • Ursula Niesert
    • 1
  1. 1.Institut für Biologie IIIFreiburg

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