The triose model: Glyceraldehyde as a source of energy and monomers for prebiotic condensation reactions

  • Arthur L. Weber
Article
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Abstract

Glyceraldehyde acts as a source of energy and monomers in a new model of the origin of life. The simplest form of the model functions by converting formaldehyde from the environment into glyceraldehyde which spontaneously forms hemiacetal adducts that are oxidized to polyglyceric acid. Polyglyceric acid, in turn, acts as an autocatalyst with a rudimentary replicating ability. A unique property of the model is its ability to unite the origin of metabolism and the origin of polymer synthesis into a single process. Furthermore, the chemical resemblance of the model to glycolysis gives it the potential to develop a biological metabolism in a straightforward manner.

Keywords

Polymer Formaldehyde Organic Chemistry Geochemistry Adduct 
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References

  1. Angyal, S. J.: 1984, in R. S. Tipson and D. Horton (eds.),Advances in Carbohydrate Chemistry and Biochemistry, Vol. 42, Academic Press, New York, pp. 15–68.Google Scholar
  2. Bar-Nun, A. and Hartman, H.: 1978,Origins of Life 9, 93–101.PubMedGoogle Scholar
  3. Bell, R. P.: 1966, in V. Gold (ed.),Advances in Physical Organic Chemistry, Vol. 4, Academic Press, New York, pp. 1–29.Google Scholar
  4. Bender, M. L.: 1971,Mechanisms of Homogeneous Catalysis from Protons to Proteins, Wiley-Interscience, New York, pp. 281–320.Google Scholar
  5. Breslow, R.: 1959,Tett. Lett., 22–26.Google Scholar
  6. Buvet, R. and LePort, L.: 1973,Space Life Sci. 4, 434–447.PubMedGoogle Scholar
  7. Buvet, R.: 1978, in H. Noda (ed.),Origin of Life, Japan Scientific Societies Press, Tokyo, pp. 411–420.Google Scholar
  8. Canuto, V. M., Levine, J. S., Augustsson, T. R., Imhoff, C. L., and Giampapa, M. S.: 1983,Nature 305, 281–286.Google Scholar
  9. Cornibert, J. and Marchessault, R. H.: 1975,Macromolecules 8, 296–305.Google Scholar
  10. Cymerman Craig, J. and Horning, E. C.: 1960,J. Org. Chem. 25, 2098–2102.Google Scholar
  11. Davidoff, O.: 1886,Ber. Dtsch. Chem. Ges. 19, 406–408.Google Scholar
  12. Davis, P. S. and Deller, D. J.: 1966,Nature 212, 404–405.PubMedGoogle Scholar
  13. Dean, J. A. (ed.): 1979,Langes Handbook of Chemistry, 12th Edition, McGraw-Hill, New York, Section 3, pp. 132–137.Google Scholar
  14. Eakin, R. E.: 1963,Proc. Nat. Acad. Sci. U.S.A. 49, 360–366.Google Scholar
  15. Fedor, L. R.: 1967,J. Am. Chem. Soc. 89, 4479–4482.PubMedGoogle Scholar
  16. Fedor, L. R.: 1969,J. Am. Chem. Soc. 91, 913–917.Google Scholar
  17. Finch, G. K.: 1960,J. Org. Chem. 25, 2219–2220.Google Scholar
  18. Fouquet, G., Merger, F., and Platz, R.: 1979,Liebigs Ann. Chem. 1591–1601.Google Scholar
  19. Gabel, N. W. and Ponnamperuma, C.: 1967,Nature 216, 453–455.PubMedGoogle Scholar
  20. Garrison, W. M., Morrison, D. C., Hamilton, J. G., Benson, A. A., and Calvin, M.: 1951,Science 114, 416–418.PubMedGoogle Scholar
  21. Geissman, T. A.: 1944, in R. Adams (ed.),Organic Reactions, Vol. II, John Wiley and Sons, New York, pp. 94–113.Google Scholar
  22. Gerstein, J. and Jencks, W. P.: 1964,J. Am. Chem. Soc. 86, 4655–4663.Google Scholar
  23. Getoff, N., Scholes, G., and Weiss, J.: 1960,Tett. Lett. 17–23.Google Scholar
  24. Guthrie, J. P.: 1977,Can. J. Chem. 55, 3562–3574.Google Scholar
  25. Harsch, G., Harsch, M., Bauer, H., and Voelter, W.: 1983,Z. Naturforsch. 38B, 1269–1280.Google Scholar
  26. Heidmann, W., Decker, P., and Pohlmann, R.: 1978, in H. Noda (ed.),Origin of Life, Japan Scientific Societies Press, Tokyo, pp. 625–630.Google Scholar
  27. Hodge, J. E.: 1955, in M. L. Wolfrom (ed.),Advances in Carbohydrate Chemistry, Vol. 10, Academic Press, New York, pp. 169–205.Google Scholar
  28. Hubbard, J. S., Hardy, J. P., and Horowitz, N. H.: 1971,Proc. Natl. Acad. Sci. U.S.A. 68, 574–578.Google Scholar
  29. Hulshof, J. and Ponnamperuma, C.: 1976,Origins of Life 7, 197–224.PubMedGoogle Scholar
  30. Jencks, W. P.: 1969a,Catalysis in Chemistry and Enzymology, McGraw-Hill, New York, pp. 154–162.Google Scholar
  31. Jencks, W. P.: 1969b, Ibid., pp. 163–242.Google Scholar
  32. Jencks, W. P.: 1969c, Ibid.,, pp. 497–501.Google Scholar
  33. Jencks, W. P.: 1976, in G. D. Fasman (ed.),Handbook of Biochemistry and Molecular Biology, 3rd Edn. Physical and Chemical Data, Vol. 1, CRC Press, Cleveland, pp. 296–304.Google Scholar
  34. Jencks, W. P. and Regenstein, J.: 1976, in G. D. Fasman (ed.),Handbook of Biochemistry and Molecular Biology, 3rd Edn. Physical and Chemical Data, Vol. 1, CRC Press, Cleveland, pp. 305–351.Google Scholar
  35. Kanchuger, M. S. and Byers, L. D.: 1979,J. Am. Chem. Soc. 101, 3005–3010.Google Scholar
  36. Kasting, J. F. and Pollack, J. B.: 1984,J. Atmos. Chem. 1, 403–428.PubMedGoogle Scholar
  37. Kokesh, F. C.: 1976,J. Org. Chem. 41, 3593–3599.Google Scholar
  38. Koskikallio, J.: 1969, in S. Patai (ed.),The Chemistry of Carboxylic Acids and Esters, Interscience Publishers, London, pp. 103–136.Google Scholar
  39. Mildvan, A. S.: 1970, in P. D. Boyer (ed.),The Enzymes, 3rd Edition, Vol. II, Academic press, New York, pp. 445–536.Google Scholar
  40. Miller, S. L.: 1957,Ann. N.Y. Acad. Sci. 69, 260–275.PubMedGoogle Scholar
  41. Miller, S. L. and Schlesinger, G.: 1984,Origins of Life 14, 83–90.PubMedGoogle Scholar
  42. Miller, S. L.: 1984,Adv. Chem. Phys. 55, 85–107.Google Scholar
  43. Mizuno, T. and Weiss, A. H.: 1974, in R. S. Tipson and D. Horton (eds.),Advances in Carbohydrate Chemistry and Biochemistry, Vol. 29, Academic Press, New York, pp. 173–227.Google Scholar
  44. Mosbach, E. H., Burns, J. J., and King, C. G.: 1951,J. Am. Chem. Soc. 73, 1874–1875.Google Scholar
  45. Ogata, Y. and Kawasaki, A.: 1970, in J. Zabicky (ed.),The Chemistry of the Carbonyl Group, Interscience Publishers, London, pp. 1–69.Google Scholar
  46. Ogata, Y., Kawasaki, A., and Kishi, I.: 1967,Tetrahedron 23, 825–830.Google Scholar
  47. Oro, J. and Stephen-Sherwood, E.: 1976,Origins of Life 7, 37–47.PubMedGoogle Scholar
  48. Pigman, W. and Anet, E. F. L. J.: 1972, in W. Pigman and D. Horton (eds.),The Carbohydrates, Vol. 1A, Academic Press, New York, pp. 165–194.Google Scholar
  49. Pinto, J. P., Gladstone, G. R., and Yung, Y. L.: 1980,Science 210, 183–185.Google Scholar
  50. Quayle, J. R. and Ferenci, T.: 1978,Microbiol. Rev. 42, 251–273.PubMedGoogle Scholar
  51. Reichstein, T.: 1934,Helv. Chim. Acta 17, 1003–1008.Google Scholar
  52. Reid, C. and Orgel, L. E.: 1967,Nature 216, 455.PubMedGoogle Scholar
  53. Reithel, F. J. and West, E. S.: 1948,J. Am. Chem. Soc. 70, 898–900.Google Scholar
  54. Rendleman, J. A.: 1966, in M. L. Wolfrom (ed.),Advances in Carbohydrate Chemistry, Vol. 21, Academic Press, New York, pp. 209–271.Google Scholar
  55. Rochester, C. H.: 1971, in S. Patai (ed.),The Chemistry of the Hydroxyl Group, Part 1, Interscience Publishers, New York, pp. 327–392.Google Scholar
  56. Schwartz, A. W.: 1971, in R. Buvet and C. Ponnamperuma (eds.),Chemical Evolution and the Origin of Life, North-Holland Publishing Co., pp. 207–215.Google Scholar
  57. Simonetta, M. and Cara, S.: 1969, in S. Patai (ed.),The Chemistry of Carboxylic Acids and Esters, Interscience Publishers, New York, pp. 1–52.Google Scholar
  58. Smith, F.: 1946, in W. W. Pigman and M. L. Wolfrom (eds.),Advances in Carbohydrate Chemistry, Vol. 2, Academic Press, New York, pp. 79–106.Google Scholar
  59. Smith, J. T. and Doctor, V. M.: 1975,J. Inorg. Nucl. Chem. 37, 775–777.Google Scholar
  60. Smith, P. A.: 1965,The Chemistry of Open-Chain Organic Nitrogen Compounds, Vol. 1, W. A. Benjamin, Inc., New York, pp. 291–341.Google Scholar
  61. Speck, J. C., Jr.: 1958, in M. L. Wolfrom (ed.),Advances in Carbohydrate Chemistry, Vol. 13, Academic Press, New York, pp. 63–103.Google Scholar
  62. Sridharan, R. and Mathai, I. M.: 1974,J. Sci. Ind. Res. 33, 178–187.Google Scholar
  63. Strehler, B. L., Schmid, P., Li, M. P., Martin, K., and Fliss, H.: 1982,J. Mol. Evol. 19, 1–8.PubMedGoogle Scholar
  64. Swain, C. G., Powell, A. L., Sheppard, W. A., and Morgan, C. R.: 1979,J. Am. Chem. Soc. 101, 3576–3583.Google Scholar
  65. Takahashi, S., Cohen, L. A., Miller, H. K., and Peake, E. G.: 1971,J. Org. Chem. 36, 1205–1209.Google Scholar
  66. Thauer, R. K., Jungermann, K., and Decker, K.: 1977,Bacteriol. Rev. 41, 100–180.PubMedGoogle Scholar
  67. Trezl, L., Rusznak, I., Tyihak, E., Szacvas, T., and Szende, B.: 1983,Biochem. J. 214, 289–292.PubMedGoogle Scholar
  68. Wagner, G.: 1878,Ber. Dtsch. Chem. Ges. 11, 679–680.Google Scholar
  69. Weber, A. L.: 1981,J. Mol. Evol. 18, 24–29.PubMedGoogle Scholar
  70. Weber, A. L.: 1984a,J. Mol. Evol. 20, 157–166.PubMedGoogle Scholar
  71. Weber, A. L.: 1984b,Origins of Life 15, 17–27.PubMedGoogle Scholar
  72. Weber, A. L.: 1985,J. Mol. Evol. 21, 351–355.PubMedGoogle Scholar
  73. Weber, A. L.: 1986,J. Mol. Evol. (submitted).Google Scholar
  74. Weber, A. L. and Miller, S. L.: 1981,J. Mol. Evol. 17, 273–284.PubMedGoogle Scholar
  75. Weber, A. L. and Orgel, L. E.: 1979,J. Mol. Evol. 13, 193–202.PubMedGoogle Scholar
  76. Wilfong, R. E.: 1961,J. Polymer Sci. 54, 385–410.Google Scholar

Copyright information

© D. Reidel Publishing Company 1987

Authors and Affiliations

  • Arthur L. Weber
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoU.S.A.

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