Phosphorylation of glyceric acid in aqueous solution using trimetaphosphate

  • Vera Kolb
  • Leslie E. Orgel


The phosphorylation of glyceric acid is an interesting prebiotic reaction because it converts a simple, potentially prebiotic organic molecule into phosphate derivatives that are central to carbohydrate metabolism. We find that 0.05 M glyceric acid in the presence of 0.5 M trimetaphosphate in alkaline solution gives a mixture of 2- and 3-phosphoglyceric acids in combined yields of up to 40%.


Phosphate Aqueous Solution Carbohydrate Organic Chemistry Geochemistry 
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3-trimethylsilyl propionic acid, sodium salt


nuclear magnetic resonance


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Vera Kolb
    • 1
  • Leslie E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA

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