Copper-catalyzed amino acid condensation in water — A simple possible way of prebiotic peptide formation
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The recently reported condensation reaction of glycine to di- and triglycine in aqueous solution in the presence of higher concentrations of sodium chloride and copper ions has been investigated systematically and quantitatively using HPLC analytical methods. The influence of ‘environmental’ factors (temperature, concentration, atmosphere) are discussed. Numerous other metal ions have been investigated with respect to similar catalytic effects, and molybdenum results as the only one inducing peptide condensation, although to a much lesser extent. Experiments based on evaporation of water and redissolution lead to peptide condensation up to (gly)6 in concentrated solutions and produces peptides even starting from initially low concentrations.
KeywordsPeptide Copper Evaporation HPLC Glycine
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