Breast Cancer Research and Treatment

, Volume 1, Issue 4, pp 287–296 | Cite as

Corpus luteum dysfunction and the epidemiology of breast cancer: A reconsideration

  • Barry M. Sherman
  • Robert B. Wallace
  • Stanley G. Korenman


Many of the epidemiologic risk factors for the development of breast cancer are related to major events in the female reproductive experience. Several years ago, in an attempt to synthesize these observations, we proposed a theory that focused on abnormal corpus luteum function as a major endocrine determinant of breast cancer risk. This review summarizes the work that has been done attempting to substantiate or refute that hypothesis and reconsiders it in the light of more recent information.


breast cancer corpus luteum epidemiology estrogen menstrual cycle progesterone 


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Copyright information

© Martinus Nijhoff Publishers 1982

Authors and Affiliations

  • Barry M. Sherman
    • 1
  • Robert B. Wallace
    • 1
  • Stanley G. Korenman
    • 2
  1. 1.Departments of Internal Medicine and Preventive MedicineUniversity of Iowa College of MedicineUSA
  2. 2.Department of MedicineUCLA-San Fernando Valley Medical ProgramUSA

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