Breast Cancer Research and Treatment

, Volume 13, Issue 1, pp 39–48

Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors

  • Ph. Terrier
  • M. J. Terrier-Lacombe
  • H. Mouriesse
  • S. Friedman
  • M. Spielmann
  • G. Contesso
Report

DOI: 10.1007/BF01806549

Cite this article as:
Terrier, P., Terrier-Lacombe, M.J., Mouriesse, H. et al. Breast Cancer Res Tr (1989) 13: 39. doi:10.1007/BF01806549

Abstract

The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival. The series comprised 17 cystosarcomas phyllodes and 16 stromal sarcomas (excluding angiosarcomas).

All tumors were reviewed and classified in similar fashion to extramammary soft tissue sarcomas. In addition, immunohistochemical studies were performed on paraffin sections with a panel of several antibodies directed against cytoskeletal filaments and cellular enzymes; five cases were also examined by electron microscopy.

Most tumors were malignant fibrous histiocytoma (21 cases) and fibrosarcoma (6 cases) types. Surgery was the main therapy. Metastasis-free survival rate was significantly correlated only with histological grade, consisting of tumor differentiation, tumor necrosis, and mitotic activity. Courses and survivals of the cystosarcoma and stromal groups were identical, questioning the clinical value of this pathologic distinction. All local recurrence, metastasis, or death occurred within 30 months, though follow-up was much longer.

Immunohistochemistry was disappointing for identification of specific histologic sub-types.

Key words

primary sarcomas breast sarcoma cystosarcoma phyllodes immunohistochemistry histograde prognosis 

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Ph. Terrier
    • 1
  • M. J. Terrier-Lacombe
    • 1
  • H. Mouriesse
    • 2
  • S. Friedman
    • 1
  • M. Spielmann
    • 3
  • G. Contesso
    • 1
  1. 1.Department of PathologyInstitut Gustave-RoussyVillejuifFrance
  2. 2.U66 INSERMInstitut Gustave-RoussyVillejuifFrance
  3. 3.Department of Adult MedicineInstitut Gustave-RoussyVillejuifFrance
  4. 4.Histologie ‘C’, Institut Gustave-RoussyVillejuif cedexFrance

Personalised recommendations