Advertisement

Breast Cancer Research and Treatment

, Volume 2, Issue 2, pp 139–150 | Cite as

Luteal phase defect and breast cancer genesis

  • Pierre Mauvais-Jarvis
  • Régine Sitruk-Ware
  • Frédérique Kuttenn
Review

Summary

The possibility that an unopposed estrogen effect mainly due to a progesterone secretion insufficiency of the corpus luteum might be involved in the promotion of human breast cancer remains a challenging hypothesis (Sherman et al.: Breast Cancer Res Treat 1:287–295, 1981). This review based upon recent data is another approach to this problem, attempting to provide a pathophysiological interpretation of breast cancer risk in terms of luteal phase insufficiency.

Keywords

Public Health Breast Cancer Estrogen Cancer Risk Progesterone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Drife JO: Evolution, menstruation and breast cancer.In RD Bulbrook and DJ Taylor (eds): Commentaries on Research in Breast Disease. Alan R Liss, New York, 1979, pp 1–23Google Scholar
  2. 2.
    Short RV: The evolution of human reproduction. Proc Roy Soc London B 195:3–24, 1976Google Scholar
  3. 3.
    Short RV, Drife JO: The aetiology of mammary cancer in men and animals. Symp Zool Soc 41 211–230, 1976Google Scholar
  4. 4.
    Morris D: The Naked Ape. Jonathan Cape, London, 1967Google Scholar
  5. 5.
    Jacobsohn D: Hormonal regulation of mammary gland growth, milk.In SK Kon and AT Cowie (eds): The Mammary Gland and its Secretion. Academic Press, New York, 1961, pp 127–160Google Scholar
  6. 6.
    Porter JC: Hormonal regulation of breast development and activity. J Invest Dermat 63:85–92, 1974Google Scholar
  7. 7.
    Milligan D, Drife JO, Short RV: Changes in breast volume during normal menstrual cycle and after oral contraceptives. Br Med J 4:494–496, 1975PubMedGoogle Scholar
  8. 8.
    Bässler R: Morphology of hormone induced structural changes in the female breast. Curr Top Pathol 53:1–89, 1970PubMedGoogle Scholar
  9. 9.
    Asboe-Hansen G: Hormonal effects on connective tissue. Physiol Rev 38:446–462, 1968Google Scholar
  10. 10.
    Cowle AT, Folley ST, Malpress FH, Richardson KC: Studies on the hormonal induction of mammary growth and lactation in the goat. J Endocr 8:64–88, 1952PubMedGoogle Scholar
  11. 11.
    Lyons WR, McGinty DA: Effects of estrone and progesterone on male rabbit mammary glands. I. Varying doses of progesterone. Proc Soc Exp Biol Med 48:83–89, 1941Google Scholar
  12. 12.
    Fournier S, Kuttenn F, de Cicco F, Baudot N, Mallet C, Mauvais-Jarvis P: Estradiol 17-hydroxysteroid dehydrogenase activity in human breast fibroadenomas. J Clin Endocrinol Metab 1982 (submitted)Google Scholar
  13. 13.
    Siiteri PK, MacDonald PC: Role of extraglandular estrogen in human endocrinology.In RO Greep and EB Astwood (eds): Handbook of Physiology II. Am. Physiol. Soc., Washington DC, 1973, pp 615–629Google Scholar
  14. 14.
    Seibold HR, Wolf RH: Neoplasms and proliferative lesions in 1065 nonhuman primate necropsies. Lab Anim Sci 23:533–539, 1973PubMedGoogle Scholar
  15. 15.
    Mauvais-Jarvis P: Adaptation de la contraception orale à la femme occidentale de la fin du XXème siècle.In INSERM (ed): Regulation de la Fécondation — Colloque INSERM 83, 1979, pp 367–382Google Scholar
  16. 16.
    Tanner JM: Trend towards earlier menarche in London, Oslo, Copenhagen, the Netherlands and Hungary. Nature 243:95–97, 1973PubMedGoogle Scholar
  17. 17.
    Doring G: The incidence of anovular cycles. J Rep Fert Suppl 6:77–81, 1969Google Scholar
  18. 18.
    Mauvais-Jarvis P, Sitruk-Ware R, Kuttenn F, Sterkers N: Luteal phase insufficiency: a common pathophysiological factor in development of benign and malignant breast diseases.In RD Bulbrook and DJ Taylor (eds): Commentaries on Research in Breast Disease. Alan Liss, New York, 1979, pp 25–59Google Scholar
  19. 19.
    Furth J: Hormones as aetiological agents in neoplasia.In FF Becker (ed): Cancer: A Comprehensive Treatise. Plenum Press, New York, 1975, pp 75–120Google Scholar
  20. 20.
    Nandi S: Role of hormones in mammary neoplasia. Cancer Res 38:4046–4049, 1978PubMedGoogle Scholar
  21. 21.
    Chalbos D, Westley B, Vignon F: Effet de l'oestradiol sur la prolifération cellulaire et l'induction d'une protéine dans un cancer du sein en culture. 2ème. Congrès Français d'Endocrinologie. Ann Endocrinol 42:35C, 1981Google Scholar
  22. 22.
    Sirbasku DA, Benson RH: Estrogen inducible growth factors that may act as mediators (estromedins).In GH Sato and R Gross (eds): Hormones and Cell Culture. CSH, 1979, pp 477–497Google Scholar
  23. 23.
    Gerschenson LH, Conner E, Murai JT: Regulation of the cell cycle by diethylstilbestrol and progesterone in cultured endometrial cells. Endocrinology 100:1468–1471, 1977PubMedGoogle Scholar
  24. 24.
    Segaloff A: Inhibition by progesterone of radiation estrogen induced mammary cancer in the rat. Cancer Res 33:1136–1137, 1973PubMedGoogle Scholar
  25. 25.
    Kuttenn F, Sitruk-Ware R, Sterkers N, Mauvais-Jarvis P: Progesterone insufficiency and benign breast disease.In CW Bardin, E Milgrom, and P Mauvais-Jarvis (eds): Progesterone and Progestins. Raven Press, New York, 1982 (in press)Google Scholar
  26. 26.
    Kuttenn F, Fournier S, Durand JC, Mauvais-Jarvis P: Estradiol and progesterone receptors in human breast fibroadenomas. J Clin Endocrinol Metab 52:1225–1229, 1981PubMedGoogle Scholar
  27. 27.
    Hsueh AJW, Peck EJ, Clark JH: Control of uterine estrogen levels by progesterone. Endocrinology 98:438–444, 1976PubMedGoogle Scholar
  28. 28.
    Tseng L, Gurpide E: Induction of human endometrial estradiol dehydrogenase by progestins. Endocrinology 97: 825–833, 1975PubMedGoogle Scholar
  29. 29.
    Mauvais-Jarvis P, Sitruk-Ware R, Kuttenn F: Benign breast disease.In WL McGuire (ed): Breast Cancer, Advances in Research and Treatment. Plenum Press, New York, 1981, pp 51–94Google Scholar
  30. 30.
    Vonderhaar BK, Smith GH, Pauley RJ, Rosen JM, Topper YJ: A difference between mammary epithelial cells from mature virgin and primiparous mice. Cancer Res 38:4059–4063, 1978PubMedGoogle Scholar
  31. 31.
    Weinstein IB: Studies on the mechanism of action of tumor promotors and their relevance to mammary carcinogenesis.In CM McGrath, MJ Brennan, and MA Rich (eds): Cell Biology of Breast Cancer. Academic Press, New York, 1980, pp 425–450Google Scholar
  32. 32.
    Coezy E, Rochefort H: Effect of pituitary isografts on the concentration of estrogen and glucocorticoïd receptors in C3H mice mammary tumors. Eur J Cancer 15:1185–1189, 1980Google Scholar
  33. 33.
    Houdebine LM: Role of progesterone in the development and the activity of the mammary gland.In CW Bardin, E Milgrom, and P Mauvais-Jarvis (eds): Progesterone and Progestins. Raven Press, New York, 1982 (in press)Google Scholar
  34. 34.
    Moolgavkar SH, Venzon DJ: Two-event models for carcinogenesis: incidence curves for childhood and adult tumors Math Biosci 47:55–77, 1979Google Scholar
  35. 35.
    Moolgavkar SH, Day NE, Stevens RC: Two stage model for carcinogenesis: epidemiology of breast cancer in females. J Natl Cancer Inst 65:559–569, 1980PubMedGoogle Scholar
  36. 36.
    Steel GG: Growth Kinetics of Tumors. Clarendon Press, Oxford, 13–15, 47–48, 1977Google Scholar
  37. 37.
    Boice JD, Stone BJ: Interaction between radiation and other breast cancer risk factors.In Late Biological Effects of Ionizing Radiation. Int. Atomic Energy Agency, Vienna, 1978, pp 231–249Google Scholar
  38. 38.
    Tokunaga M, Normal JE Jr, Asano M: Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki. J Natl Cancer Inst 62:1347–1359, 1979PubMedGoogle Scholar
  39. 39.
    Macmahon B, Cole P, Lin TM: Age at first birth and breast cancer risk. Bull WHO 13:209–221, 1970Google Scholar
  40. 40.
    Macmahon B, Cole P, Brown J: Etiology of human breast cancer: a review. J Natl Cancer Inst 50:21–42, 1973PubMedGoogle Scholar
  41. 41.
    Winder EL, Bross IJ, Hirayama T: A study of the epidemiology of cancer of the breast. Cancer 13:559–601, 1960PubMedGoogle Scholar
  42. 42.
    Vorherr H, Messer RH: Breast cancer potentially predisposing and protecting factors. Role of pregnancy, lactation, and endocrine status. Am J Obstet Gynecol 130:335–358, 1978PubMedGoogle Scholar
  43. 43.
    Anderson DE: Breast cancer in families. Cancer 30:1855–1860, 1977Google Scholar
  44. 44.
    King MC, Go RC, Elston RC, Lynch HT, Petrakis NL: Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. Science 208:406–408, 1980PubMedGoogle Scholar
  45. 45.
    Azzopardi JG: Cystic disease and carcinoma.In JG Azzopardi (ed): Problems in Breast Pathology. WD Saunders, Philadelphia, 1979, pp 92–112Google Scholar
  46. 46.
    Haagensen CD, Lane N, Lattes R: Lobular neoplasia (so called lobular carcinoma in situ) of the breast. Cancer 42:737–769, 1978PubMedGoogle Scholar
  47. 47.
    Cowan LD, Gordis L, Tonascia JA, Seegar-Jones G: Breast cancer incidence in women with a history of progesterone deficiency. Am J Epidemiol 114:209–217, 1981PubMedGoogle Scholar
  48. 48.
    Korenman S: The endocrinology of breast cancer. Cancer 46:874–878, 1980PubMedGoogle Scholar
  49. 49.
    Sitruk-Ware RL, Sterkers N, Mowszowics I, Mauvais-Jarvis P: Inadequate corpus luteal function in women with benign breast disease. J Clin Endocrinol Metab 44:771–774, 1977PubMedGoogle Scholar
  50. 50.
    Marshall WA, Tanner JM: Variations in pattern of pubertal changes in girls. Arch Dis Child 44:291–292, 1969PubMedGoogle Scholar
  51. 51.
    Sherman BM, Korenman SG: Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Invest 55:699–706, 1975PubMedGoogle Scholar
  52. 52.
    Treloar AE, Boynton RE, Behn BG, Brown BW: Variation of the menstrual cycle through reproductive life. Int J Fert 12:77–82, 1967Google Scholar
  53. 53.
    Schaefer O: Cancer of the breast and lactation. Can Med Assoc J 100:625–626, 1969PubMedGoogle Scholar
  54. 54.
    Hoover R, Gray LA, Cole P, MacMahon B: Menopausal estrogens and breast cancer. N Engl J Med 295:401–405, 1976PubMedGoogle Scholar
  55. 55.
    Sherman BM, Korenman SG: Inadequate corpus luteum function: A pathophysiological interpretation of human breast cancer epidemiology. Cancer 33:1306–1311, 1974PubMedGoogle Scholar
  56. 56.
    Grattarola R: The premenstrual endometrial pattern of women with breast cancer. Cancer 17:1119–1122, 1964PubMedGoogle Scholar
  57. 57.
    Lilienfeld AM: Relationship of cancer of the female breast to artificial menopause and marital status. Cancer 9:927–934, 1956PubMedGoogle Scholar
  58. 58.
    Feinleib M: Breast cancer and artifical menopause: a cohort study. J Natl Cancer Inst 41:316–329, 1968Google Scholar
  59. 59.
    Feinleib M, Garrison RJ: Interpretation of the vital statistics of breast cancer. Cancer 24:1109–1116, 1969PubMedGoogle Scholar
  60. 60.
    Haenzel W, Kurihara M: Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst 40:43–68, 1968PubMedGoogle Scholar
  61. 61.
    Haagensen CD: The etiology of the breast.In CD Haagensen (ed): Diseases of the Breast. WB Saunders, Philadelphia, 1971, pp 354–379Google Scholar
  62. 62.
    Matsumoto S, Igarashi M, Nagaoka Y: Environmental anovulatory cycles. Int J Fertil 13:15–23, 1968PubMedGoogle Scholar
  63. 63.
    Lachelin GCL, Yen SSC: Hypothalamic chronic anovulation. Am J Obstet Gynecol 130:825–831, 1978PubMedGoogle Scholar
  64. 64.
    Wat SY, Hodge RW: Social and economic factors in Hong Kong's fertility decline. Popul Stud 26:455–461, 1972Google Scholar
  65. 65.
    Davis HH, Simons M, Davis JB: Cystic disease of the breast relationship to carcinoma. Cancer 17:957–978, 1964PubMedGoogle Scholar
  66. 66.
    Wardlaw SL, Wehrenberg WB, Ferin M, Frantz AG: Failure of endorphin to stimulate prolactin release in the pituitary stalk-sectioned monkey. Endocrinology 107: 1663–1666, 1980PubMedGoogle Scholar
  67. 67.
    Noel GL, Suh HK, Stone JG, Frantz AG: Human prolactin and growth hormone release during surgery and other conditions of stress. J Clin Endocrinol Metab 35:840–851, 1972PubMedGoogle Scholar
  68. 68.
    Peters F, Pickardt CR, Zimmerman N, Breckwoldt M: PRL, TSH and thyroid hormones in benign breast diseases. Klin Wochenschrift 59:403–407, 1981Google Scholar
  69. 69.
    Peillon F, Vincens M, Cesselin F, Doumith R, Mowszowicz I: Cycles anovulatoires avec normoprolactinémie apparente. Traitement par la Bromocryptine. Nouv Presse Med 8: 3269–3275, 1979Google Scholar

Copyright information

© Martinus Nijhoff Publishers 1982

Authors and Affiliations

  • Pierre Mauvais-Jarvis
    • 1
  • Régine Sitruk-Ware
    • 1
  • Frédérique Kuttenn
    • 1
  1. 1.Department of Reproductive EndocrinologyFaculté de Médecine NeckerParis Cedex 15France

Personalised recommendations