Breast Cancer Research and Treatment

, Volume 2, Issue 2, pp 139–150 | Cite as

Luteal phase defect and breast cancer genesis

  • Pierre Mauvais-Jarvis
  • Régine Sitruk-Ware
  • Frédérique Kuttenn


The possibility that an unopposed estrogen effect mainly due to a progesterone secretion insufficiency of the corpus luteum might be involved in the promotion of human breast cancer remains a challenging hypothesis (Sherman et al.: Breast Cancer Res Treat 1:287–295, 1981). This review based upon recent data is another approach to this problem, attempting to provide a pathophysiological interpretation of breast cancer risk in terms of luteal phase insufficiency.


Public Health Breast Cancer Estrogen Cancer Risk Progesterone 
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Copyright information

© Martinus Nijhoff Publishers 1982

Authors and Affiliations

  • Pierre Mauvais-Jarvis
    • 1
  • Régine Sitruk-Ware
    • 1
  • Frédérique Kuttenn
    • 1
  1. 1.Department of Reproductive EndocrinologyFaculté de Médecine NeckerParis Cedex 15France

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