Breast Cancer Research and Treatment

, Volume 40, Issue 1, pp 11–24

Breast cancer in African American women: Epidemiology and tumor biology

  • Bruce J. Trock
Guest editor's introduction

Summary

This review of published data on the epidemiology, pathology, and molecular biology of breast cancer in African American women seeks to identify how the etiology and presentation of the disease differ from those in white women. The crossover from higher to lower age-specific incidence rates in African American women at age 45 cannot be explained by current data on the distribution of risk factors. Data from six case-control studies suggest that the relative risks associated with both established and probable breast cancer risk factors are similar in African American and white women. Lower survival in African American compared to white women is primarily attributable to diagnosis at a later stage. However, evidence from a number of studies suggests that tumors in African American women may exhibit a more aggressive phenotype, which could also contribute to the survival disparity. Tumors in African American women are more likely to occur at a younger age, to be poorly differentiated and estrogen receptor negative, and to exhibit high grade nuclear atypia, more aggressive histology (more medullary and less lobular), and higher S-phase. Overexpression of p53 and erbB-2 occurs with similar frequency in African American and white women, although limited data suggest the former may exhibit different p53 mutation spectra. One study found high risk associated with a specific CYP1A1 polymorphism in African American but not white women. Additional studies of molecular differences in African American and white women are needed, with multifactorial assessment of the independent effects of molecular and conventional risk attributes.

Key words

risk factors molecular markers estrogen receptor p53 erbB-2 CYP1A1 

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Bruce J. Trock
    • 1
  1. 1.Lombardi Cancer CenterGeorgetown University Medical CenterWashington DCUSA

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