Determination of the levels of prostaglandin E2 (PGE2) and PGF2α were carried out using homogenized primary human breast tumors. Measurable levels of both prostaglandins were found in all but one tumor examined. In most samples, the absolute PGF2α level was higher than that of PGE2. Higher PGE2 levels are more often seen in postmenopausal women than in pre- or perimenopausal patients, though among postmenopausal women, PGE2 levels do not correlate with age. Thus, the ratio of PGF:PGE is higher in pre/perimenopausal women than in postmenopausal women. Differences in PGF2α do not appear to be associated with age or menopausal status.
Tumors that are estrogen receptor positive (ER +) tend to have higher PGE2 levels than ER negative tumors. PGF2α is not associated with the presence of ER and neither prostaglandin is associated with the presence of progesterone receptor. Higher levels of both PGE2 and PGF2α are associated with less differentiated tumors, while tumor maximum diameter is negatively associated with PGE2 levels.
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Fulton, A., Roi, L., Howard, L. et al. Tumor-associated prostaglandins in patients with primary breast cancer: Relationship to clinical parameters. Breast Cancer Res Tr 2, 331–337 (1982). https://doi.org/10.1007/BF01805874
- breast cancer
- clinical correlates