Journal of Inherited Metabolic Disease

, Volume 19, Issue 5, pp 621–623

Pregnancy and argininosuccinic aciduria

  • S. Worthington
  • J. Christodoulou
  • B. Wilcken
  • B. Peat
Article

Summary

We present the outcome of a pregnancy in a woman with mild argininosuccinic lyase deficiency to add to the collective experience of the maternal and fetal effects of urea cycle defects. In females affected with argininosuccinic lyase deficiency, careful clinical and biochemical monitoring of pregnancy will minimize the risk of metabolic decompensation in the perinatal period. Furthermore, it would appear that argininosuccinate is not teratogenic to the development of the human fetus.

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Copyright information

© SSIEM and Kluwer Academic Publishers 1996

Authors and Affiliations

  • S. Worthington
    • 1
  • J. Christodoulou
    • 1
    • 2
  • B. Wilcken
    • 1
  • B. Peat
    • 3
  1. 1.Western Sydney Genetics ProgramWestmead
  2. 2.Department of Paediatrics and Child HealthUniversity of SydneySydney
  3. 3.Department of PerinatologyRoyal Prince Alfred HospitalCamperdownAustralia
  4. 4.University Department of Paediatrics and Child HealthRoyal Alexandra Hospital for ChildrenWestmeadAustralia

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