Reversal of clinical features of hurler's disease and biochemical improvement after treatment by bone marrow transplantation

  • J. R. Hobbs
  • K. Hugh Jones
  • A. J. Barrett
  • N. Byrom
  • D. Chambers
  • K. Henry
  • D. C. O. James
  • C. F. Lucas
  • T. R. Rogers
  • P. F. Benson
  • L. R. Tansley
  • J. Mossman
  • F. P. Young
  • A. D. Patrick
Short Communication

Keywords

Public Health Bone Marrow Internal Medicine Metabolic Disease Bone Marrow Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Dean, M. F., Benson, P. F. and Muir, H. Mobilisation of glycosaminoglycans by plasma infusions in mucopolysaccharidosis Type III—Two types of response.Nature New Biol. 243 (1973) 143–146Google Scholar
  2. Dean, M. F., Muir, H., Benson, P. F., Button, L. R., Batchelor, J. P. and Bewick, M. Increased breakdown of glycosaminoglycans and appearance of corrective enzyme after skin transplants in Hunter syndrome.Nature (Lond.) 257 (1975) 609–612Google Scholar
  3. Dean, M. F., Muir, H., Benson, P. F., Button, L. R., Boylston, A. and Mowbray, J. Enzyme replacement therapy by fibroblast transplantation in a case of Hunter syndrome.Nature (Lond.) 261 (1976) 323–325Google Scholar
  4. Dean, M. F., Stevens, R. L., Muir, H., Benson, P. F., Button, L. R., Anderson, R. L., Boylston, A. and Mowbray, J. Enzyme replacement therapy by fibroblast transplantation. Long-term biochemical study in three cases of Hunter's syndrome.J. Clin. Invest. 63 (1979) 138–145Google Scholar
  5. Dean, M. F., Muir, H., Benson, P. F. and Button, L. R. Enzyme replacement therapy by transplantation of HLA-compatible fibroblasts in Sanfilippo A syndrome.Pediatr. Res. 15 (1969) 959–963Google Scholar
  6. Di Ferrante, N., Nichols, B., Donnelly, P. V., Neri, G., Hrgovcic, R. and Berglund, R. K. Induced degradation of glycosaminoglycans in Hurler's and Hunter's syndromes by plasma infusion.Proc. Natl. Acad. Sci. USA 68 (1971) 303–307Google Scholar
  7. Fratantoni, J. C., Hall, C. W. and Neufeld, E. F. Hurler and Hunter syndromes: mutual correction of the defect in cultured fibroblasts.Science (Wash. DC) 162 (1968) 500–572Google Scholar
  8. Hobbs, J. R., Hugh-Jones, K., Barrett, A. J., Byrom, N., Chambers, D., Henry, K., James, D. C. O., Lucas, C. F., Rogers, T. R., Benson, P. F., Tansley, L. R., Mossman, J., Young, E. P. and Patrick, A. D. Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone marrow transplantation.Lancet 2 (1981) 709–712Google Scholar
  9. Knudson, A. G., Di Ferrante, N. and Curtis, J. E. Effect of leucocyte transfusion in a child with type II mucopolysaccharidosis.Proc. Natl. Acad. Sci. USA 68 (1971) 1738–1741Google Scholar
  10. Moser, H. W., O'Brien, J. S., Atkins, L., Fuller, T. C., Keiman, A., Janowska, S., Russell, P. F., Bartsocas, C. S., Cosimi, B. and Dulaney, J. T. Infusion of normal HLA identical leucocytes in Sanfilippo disease type B.Arch. Neurol. 31 (1974) 329–337Google Scholar

Copyright information

© MTP Press Limited 1982

Authors and Affiliations

  • J. R. Hobbs
    • 1
  • K. Hugh Jones
    • 1
  • A. J. Barrett
    • 1
  • N. Byrom
    • 1
  • D. Chambers
    • 1
  • K. Henry
    • 1
  • D. C. O. James
    • 1
  • C. F. Lucas
    • 1
  • T. R. Rogers
    • 1
  • P. F. Benson
    • 2
  • L. R. Tansley
    • 2
  • J. Mossman
    • 3
  • F. P. Young
    • 3
  • A. D. Patrick
    • 3
  1. 1.Westminster Hospital Bone Marrow Transplant TeamLondon
  2. 2.Paediatric Research Unit, The Prince Philip Research LaboratoriesGuy's Hospital Medical SchoolLondon
  3. 3.Institute of Child HealthUniversity of LondonLondon

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