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Regional distribution of the phenylalanine-sensitive ATP-sulphurylase in brain

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Abstract

The regional distribution of the phenylalanine-sensitive ATP-sulphurylase in fetal calf brain coincides with demyelinated lesions observed in the central nervous systems of untreated PKU patients. This would be expected if this species of ATP-sulphurylase played a role in the pathogenesis of brain dysfunction in the untreated or poorly controlled phenylketonuria patient.

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References

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Matsuo, K., Hommes, F. Regional distribution of the phenylalanine-sensitive ATP-sulphurylase in brain. J Inherit Metab Dis 10, 62–65 (1987). https://doi.org/10.1007/BF01799489

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Keywords

  • Public Health
  • Nervous System
  • Central Nervous System
  • Internal Medicine
  • Metabolic Disease