The International Journal of Cardiac Imaging

, Volume 5, Issue 4, pp 227–231 | Cite as

Is technetium-99 m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis?

  • A. Hartmann
  • J. Frenkel
  • R. Hopf
  • R. P. Baum
  • G. Hör
  • M. Schneider
  • M. Kaltenbach


Amyloidosis is a systemic disease frequently involving the myocardium and leading to functional disturbances of the heart. Amyloidosis can mimic other cardiac diseases. A conclusive clinical diagnosis of cardiac involvement can only be made by a combination of different diagnostic methods. In 7 patients with myocardial amyloidosis we used a combined first-pass and static scintigraphy with technetium-99 m-pyrophosphate. There was only insignificant myocardial uptake of the tracer. The first-pass studies however revealed reduced systolic function in 4/7 patients and impaired diastolic function in 6/7 patients. Therefore, although cardiac amyloid could not be demonstrated in the static scintigraphy due to amyloid fibril amount and composition, myocardial functional abnormalities were seen in the first-pass study.

Key words

cardiac amyloidosis cardiomyopathy technetium-99 m-pyrophosphate scintigraphy diastolic function 


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • A. Hartmann
    • 3
  • J. Frenkel
    • 3
  • R. Hopf
    • 3
  • R. P. Baum
    • 1
  • G. Hör
    • 1
  • M. Schneider
    • 2
  • M. Kaltenbach
    • 3
  1. 1.Dept. of Nuclear MedicineFrankfurt University Medical CenterFrankfurt 70West-Germany
  2. 2.Dept. of PathologyFrankfurt University Medical CenterFrankfurt 70West-Germany
  3. 3.Dept. of CardiologyFrankfurt University Medical CenterFrankfurt 70FRG

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