Journal of Molecular Evolution

, Volume 9, Issue 3, pp 203–211

Standard error of immunological dating of evolutionary time

  • Masatoshi Nei

DOI: 10.1007/BF01796109

Cite this article as:
Nei, M. J Mol Evol (1977) 9: 203. doi:10.1007/BF01796109


The empirical variance of the immunological distance as measured by microcomplement fixation with albumin is determined. The variance obtained is at least two times larger than the mean when the mean is small and the ratio of the variance to the mean increases with increasing mean. Thus, the immunological dating of evolutionary time has a large standard error. It is shown that in bird lysozymes the relationship between immunological distance (y) and the number of amino acid substitutions per 100 sites (x) is given byy = 4.2x approximately.

Key words

Immunological distance Molecular evolution 

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Masatoshi Nei
    • 1
  1. 1.Center for Demographic and Population GeneticsUniversity of Texas at HoustonHoustonUSA

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