Clinical & Experimental Metastasis

, Volume 7, Issue 2, pp 127–167 | Cite as

Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis

  • Leonard Weiss
  • F. William Orr
  • Kenneth V. Honn


Hematogenous metastasis is a major consideration in the staging, treatment and prognosis of patients with cancer. Key events affecting hematogeneous metastasis occur in the microvasculature. This is a brief, selective review of some interactions involving cancer cells and the microvasculature in pathologic sequence, specifically: (1) intravasation of cancer cells; (2) the arrest of circulating cancer cells in the microvasculature; (3) cancer cell trauma associated with arrest; (4) microvascular trauma; (5) the inflammatory; and (6) the hemostatic coagulative responses associated with arrest, and finally (7) angiogenesis, leading to tumor vascularization. The evidence shows that through a series of complex interactions with cancer cells, the microvasculature acts as a rate-regulator for the metastatic process, in addition to providing routes for cancer cell dissemination and arrest sites for cancer cell emboli.


Public Health Cancer Cell Cancer Research Complex Interaction Tumor Vascularization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Taylor & Francis Ltd 1989

Authors and Affiliations

  • Leonard Weiss
    • 1
  • F. William Orr
    • 2
  • Kenneth V. Honn
    • 3
    • 4
  1. 1.Department of Experimental PathologyRoswell Park, Memorial InstituteBuffaloUSA
  2. 2.Department of PathologyMcMaster UniversityHamiltonCanada
  3. 3.Department of Radiation OncologyWayne State UniversityDetroitUSA
  4. 4.Gershenson Radiation Oncology CenterHarper/Grace HospitalsDetroitUSA

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