Clinical & Experimental Metastasis

, Volume 6, Issue 2, pp 115–120

Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan

  • J. Beuth
  • H. L. Ko
  • V. Schirrmacher
  • G. Uhlenbruck
  • G. Pulverer
Article

Abstract

Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • J. Beuth
    • 1
  • H. L. Ko
    • 1
  • V. Schirrmacher
    • 2
  • G. Uhlenbruck
    • 3
  • G. Pulverer
    • 1
  1. 1.Institute of HygieneUniversity of CologneCologne 41F.R. Germany
  2. 2.Deutsches KrebsforschungszentrumHeidelbergF.R. Germany
  3. 3.Department of ImmunobiologyMedical University Clinic ICologne 41F.R. Germany

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