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Oncogene expression in related cancer lines differing in metastatic capacity


Various murine tumor cell lines with different metastatic capacities were testedin vitro for oncogene expression, especially of the p21-Ha-ras protein. Small differences were seen in the expression of several distinct oncogenes in the case of a high metastatic lymphoma variant (ESb) and its low metastatic parental line (Eb). In one instance we observed a 30-fold Ha-ras gene amplification in a metastasis-derived cell line from a spontaneous mouse mammary carcinoma. In spite of this amplification we did not find an increased p21 expression in these cells.

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Pohl, J., Radler-Pohl, A., Heicappell, R. et al. Oncogene expression in related cancer lines differing in metastatic capacity. Clin Exp Metast 6, 201–211 (1988).

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  • Lymphoma
  • Tumor Cell Line
  • Parental Line
  • Gene Amplification
  • Mammary Carcinoma