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Inflammation Research

, Volume 44, Supplement 2, pp S117–S118 | Cite as

Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits

  • E. M. O'Byrne
  • D. T. Parker
  • E. D. Roberts
  • R. L. Goldberg
  • L. J. MacPherson
  • V. Blancuzzi
  • D. Wilson
  • H. N. Singh
  • R. Ludewig
  • V. S. Ganu
I. Cartilage degradation and osteoarthritis

Keywords

Osteoarthritis Oral Administration Matrix Metalloproteinase Partial Meniscectomy Metalloproteinase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner JF. Evidence for metalloprotease and metalloprotease inhibitor imbalance in human osteoarthritic cartilage. J Clin Invest 1989;84:678–85.Google Scholar
  2. [2]
    Mehraban F, Kou Riera HSY, Chang C, Moskowitz RW. Prostromelysin and procollagenase genes are up-regulated in chondrocytes from knees of rabbits with experimental osteoarthritis. Arth Rheum 1994;37:1189–97.Google Scholar
  3. [3]
    Colombo C, Butler M, O'Byrne E, Hickman L, Swartzendruber D, Selwyn M, et al. A new model of osteoarthritis in rabbits 1. development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments. Arth Rheum 1983;26:875–86.Google Scholar
  4. [4]
    Greenwald RA, Moak SA, Ramamurthy NS, Golub LM. Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flubiprofen ameliorate bone damage. J Rheumatol 1992;19:927–38.PubMedGoogle Scholar
  5. [5]
    Rubin AS, Roberts ED. Morphometric quantitation of histopathologic changes in articular cartilage in an immunologically-induced rabbit model of rheumatoid arthritis. Lab Invest 1987;57:342–6.PubMedGoogle Scholar
  6. [6]
    O'Byrne EM, Paul PK, Roberts ED, Blancuzzi V, Wilson D, Goldberg RL. Comparison of magnetic resonance imaging (MRI) and histopathology in rabbit models of osteoarthritis and immune arthritis. Agents Actions 1993;39:157–9.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1995

Authors and Affiliations

  • E. M. O'Byrne
    • 2
  • D. T. Parker
    • 2
  • E. D. Roberts
    • 1
    • 2
  • R. L. Goldberg
    • 2
  • L. J. MacPherson
    • 2
  • V. Blancuzzi
    • 2
  • D. Wilson
    • 2
  • H. N. Singh
    • 2
  • R. Ludewig
    • 2
  • V. S. Ganu
    • 2
  1. 1.Delta Regional Primate CenterTulane UniversityCovingtonUSA
  2. 2.Research Department, Pharmaceuticals DivisionCiba-Geigy CorporationSummitUSA

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