Cancer Immunology, Immunotherapy

, Volume 32, Issue 3, pp 191–194

Analysis of natural killer activity and natural killer cell subsets in patients with bladder cancer

  • Tatsuo Morita
  • Akihiko Tokue
  • Nagahiro Minato
Original articles

DOI: 10.1007/BF01771456

Cite this article as:
Morita, T., Tokue, A. & Minato, N. Cancer Immunol Immunother (1990) 32: 191. doi:10.1007/BF01771456

Summary

In order to analyze the state of the natural resistance system of bladder cancer patients in vivo, we measured natural killer (NK) activity and NK cell subsets of peripheral blood lymphocytes (PBL) from 46 patients with bladder cancer and 25 age- and sex-matched healthy volunteers. The mean NK activity in patients with lowstage bladder cancer was similar to that in the controls, while NK activity in patients with high-stage bladder cancer was significantly depressed. The mean proportions of Leu7+ cells in patients with both low-stage and highstage bladder cancer were significantly higher than that in the controls. The mean proportion of Leu11a+ cells in patients with low-stage bladder cancer was similar to that in the controls, while in patients with high-stage bladder cancer it was significantly higher. This study demonstrates the abnormal immunological state of bladder cancer patients; namely, abnormalities exist not only in NK activity but also in the proportions of circulating NK cell subsets.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Tatsuo Morita
    • 1
  • Akihiko Tokue
    • 1
  • Nagahiro Minato
    • 2
  1. 1.Department of UrologyJichi Medical SchoolTochigiJapan
  2. 2.Department of MedicineJichi Medical SchoolTochigiJapan

Personalised recommendations