Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Detoxification of cyanide in a new-born child

Entgiftung von Zyanid bei einem neugeborenen Kind

Summary

A well-developed male baby was given infusions of 2–5 µg/kg/min of sodium nitroprusside (SNP) in the first few days after birth on account of high arterial blood pressure. After 30 h of treatment, cyanide accumulation was found to have reached a life-threatening level. IV administration of 100 mg/kg of sodium thiosulphate promptly lowered the cyanide level. The mixed infusion of SNP together with thiosulphate, used in the subsequent course, was no longer toxic.

Zusammenfassung

Ein reifer männlicher Säugling bekam wegen einer arteriellen Hypertonie in den ersten Lebenstagen 2–5 µg/kg/min Nitroprussid-Natrium (NPN) infundiert. Nach 30stündiger Therapie wurde eine lebensbedrohliche Zyanidkumulation festgestellt. Der Zyanidspiegel konnte mit 100 mg/kg Natriumthiosulfat i.v. prompt gesenkt werden. Die Mischinfusion von NNP zusammen mit Thiosulfat war im weiteren Verlauf nicht mehr toxisch.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Abbott TR, Rees GJ, Dickinson D, Reynolds G, Lord D (1978) Sodium nitroprusside in idopathic respiratory distress syndrome. Br Med J 1:1113–4

  2. 2.

    Bennett NR, Abbott TR 1977 The use of sodium nitroprusside in children. Anaesthesia 32:456–463

  3. 3.

    Beverley DW, Hughes CA, Davies DP, Harran MJ, Ducker DA 1979 Early use of sodium nitroprusside in respiratory distress syndrome. Arch Dis Child 54:403–404

  4. 4.

    Dillon TR, Janos GG, Meyer RA, Benzing G, Kaplan S 1980 Vasodilator therapy for congestive heart failure. J Pediatr 96:623–629

  5. 5.

    Elberg AJ, Gorman HM, Baker R, Strauss J 1979 Use of sodium nitroprusside in hypertension crisis in children. Cardiovasc Med 484–502

  6. 6.

    Luderer JR, Hayes AH, Dubynsky O, Berlin CM 1977 Long-term administration of sodium nitroprusside in childhood. J Padiatr 91:490–491

  7. 7.

    Lupatkin WL, Morrison S, Challop R 1978 Prolonged use of sodium nitroprusside. J Pediatr 92:1032–1033

  8. 8.

    Schulz V, Gross R, Pasch T, Busse J, Loeschcke G (1982) Toxicity of sodium nitroprusside in therapeutic use with and without sodium thiosulphate. Klin Wochenschr (in press)

  9. 9.

    Schulz B, Löffler A, Thon HJ (1982) Resorption von Blausäure aus Kaliumzyanid, Bittermandeln und Leinsamen. Klin Wochenschr (in press)

  10. 10.

    Turmen TT, Davis JM, Aranda JV 1980 Sodium nitroprusside and RDS — primum non nocere. Arch Dis Child 55:82–83

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schulz, V., Roth, B. Detoxification of cyanide in a new-born child. Klin Wochenschr 60, 527–528 (1982). https://doi.org/10.1007/BF01756099

Download citation

Key words

  • Nitroprusside
  • Cyanide
  • Thiosulfate
  • New-born child

Schlüsselwörter

  • Nitroprussid
  • Zyanid
  • Thiosulfat
  • neugeborenes Kind