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Detoxification of cyanide in a new-born child

Entgiftung von Zyanid bei einem neugeborenen Kind


A well-developed male baby was given infusions of 2–5 µg/kg/min of sodium nitroprusside (SNP) in the first few days after birth on account of high arterial blood pressure. After 30 h of treatment, cyanide accumulation was found to have reached a life-threatening level. IV administration of 100 mg/kg of sodium thiosulphate promptly lowered the cyanide level. The mixed infusion of SNP together with thiosulphate, used in the subsequent course, was no longer toxic.


Ein reifer männlicher Säugling bekam wegen einer arteriellen Hypertonie in den ersten Lebenstagen 2–5 µg/kg/min Nitroprussid-Natrium (NPN) infundiert. Nach 30stündiger Therapie wurde eine lebensbedrohliche Zyanidkumulation festgestellt. Der Zyanidspiegel konnte mit 100 mg/kg Natriumthiosulfat i.v. prompt gesenkt werden. Die Mischinfusion von NNP zusammen mit Thiosulfat war im weiteren Verlauf nicht mehr toxisch.

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Schulz, V., Roth, B. Detoxification of cyanide in a new-born child. Klin Wochenschr 60, 527–528 (1982).

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Key words

  • Nitroprusside
  • Cyanide
  • Thiosulfate
  • New-born child


  • Nitroprussid
  • Zyanid
  • Thiosulfat
  • neugeborenes Kind