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Klinische Wochenschrift

, Volume 44, Issue 6, pp 334–337 | Cite as

Doppel-Philadelphia-Chromosom und Isochromosom 17 in der terminalen Phase der chronischen myeloischen Leukämie

  • W. Stich
  • F. Back
  • P. Dörmer
  • A. Tsirimbas
Originalien

Zusammenfassung

Bei einer chronischen myeloischen Leukämie mit Osteomyelosklerose konnte in der terminalen Phase mit Hilfe der cytogenetischen und autoradiographischen Untersuchung der Chromosomen eine Hyperdiploidie von 48 Chromosomen mit zwei Philadelphia-Chromosomen, einem wahrscheinlichen Isochromosom 17 und einem Extrachromosom der Gruppe Nr. 6–12 nachgewiesen werden. Die Bedeutung der Chromosomenbefunde und ihr Zusammenhang mit den hämatologischen und klinischen Befunden werden diskutiert.

Summary

In the terminal stage of a chronic myelogenous leukemia with osteomyelosclerosis cytogenetic and autoradiographic studies of the chromosomes disclosed hyperdiploidia of 48 chromosomes with 2 Philadelphia chromosomes, one probable isochromosome 17 and one extrachromosome of group no. 6 to 12. The importance of the chromosome findings and their relation with the hematological and clinical findings are discussed.

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • W. Stich
    • 1
    • 2
  • F. Back
    • 1
    • 2
  • P. Dörmer
    • 1
    • 2
  • A. Tsirimbas
    • 1
    • 2
  1. 1.Institut für Hämatologie der GSF, Assoziation mit EURATOMMünchenGermany
  2. 2.Medizinische Klinik der Universität MünchenGermany

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