Heart and Vessels

, Volume 12, Issue 1, pp 43–48

Evolution to dilated cardiomyopathy from acute eosinophilic pancarditis in Churg-Strauss syndrome

  • Fumio Terasaki
  • Tetsuya Hayashi
  • Yuzo Hirota
  • Makoto Okabe
  • Michihiro Suwa
  • Hirofumi Deguchi
  • Yasushi Kitaura
  • Keishiro Kawamura
Case reports

DOI: 10.1007/BF01747501

Cite this article as:
Terasaki, F., Hayashi, T., Hirota, Y. et al. Heart Vessels (1997) 12: 43. doi:10.1007/BF01747501

Summary

We describe the clinical manifestations of a patient with Churg-Strauss syndrome who presented with severe acute cardiac involvement and whose disease evolved to dilated cardiomyopathy (DCM), with special reference to the histopathological findings. Endomyocardial biopsies, conducted sequentially, three times within 10 months, revealed severe eosinophilic endomyocarditis in the acute phase, interstitial fibrosis in the subacute phase, and endocardial thickening with mural thrombi, at 10 months. Although acute inflammation associated with elevation of eosinophil granule proteins subsided with steroid therapy, left ventricular dilatation with reduced contractility progressed. A subgroup of DCM is not considered to be idiopathic but, rather, an aftereffect of hypereosinophilic heart disease.

Key words

Hypereosinophilic heart disease Endomyocardial biopsy Churg-Strauss syndrome Dilated cardiomyopathy 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Fumio Terasaki
    • 1
  • Tetsuya Hayashi
    • 1
  • Yuzo Hirota
    • 1
  • Makoto Okabe
    • 1
  • Michihiro Suwa
    • 1
  • Hirofumi Deguchi
    • 1
  • Yasushi Kitaura
    • 1
  • Keishiro Kawamura
    • 1
  1. 1.Third Division, Department of Internal MedicineOsaka Medical CollegeOsakaJapan

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