Heart and Vessels

, Volume 11, Issue 6, pp 277–280

HLA-DR6 (possibly DRB1*1301) is associated with susceptibility to Takayasu arteritis in Mexicans

  • Eduardo Girona
  • Jesús K. Yamamoto-Furusho
  • Teresa Cutiño
  • Pedro Reyes
  • Gilberto Vargas-Alarcón
  • Julio Granados
  • Donato Alarcón-Segovia
Originals

DOI: 10.1007/BF01747186

Cite this article as:
Girona, E., Yamamoto-Furusho, J.K., Cutiño, T. et al. Heart Vessels (1996) 11: 277. doi:10.1007/BF01747186

Summary

Takayasu arteritis is characterized by a “pulseless” condition and occurs frequently in young females from Asian and South American countries. This disease has been found to be linked with major histocompatibility complex (MHC) antigens in Japanese individuals. In the present study we compared gene frequencies of class I, class II, and class III MHC genotypes in patients with Takayasu arteritis and ethnically matched healthy controls. Serological typing was confirmed by molecular typing at the DNA level. We found significant increases in the frequencies of human leucocyte antigen (HLA)-DR6 and HLA-B62 in patients compared to the healthy controls (P corrected [C] = 0.0007, relative risk [RR] = 5.08;PC = 0.05, RR = 3.13 respectively). However, since the number of patients was considerably lower than the number of controls this can be considered as a tendency and not a true association. On the other hand, we found a significantly decreased frequency of HLA-DR4 in patients compared to healthy controls (PC = 0.04, RR = 0.34). At the DNA level, all DR6-positive individuals were HLA-DRB1*1301 whereas controls were HLA-DRB1*1301 (4.2%). Takayasu arteritis in Mexicans is probably associated with the HLA-DR6 (DRB1*1301) gene.

Key words

Major histocompatibility complex (MHC) HLA antigens Takayasu arteritis 

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Eduardo Girona
    • 1
  • Jesús K. Yamamoto-Furusho
    • 2
  • Teresa Cutiño
    • 1
  • Pedro Reyes
    • 1
  • Gilberto Vargas-Alarcón
    • 2
  • Julio Granados
    • 2
  • Donato Alarcón-Segovia
    • 2
  1. 1.Department of ImmunologyInstituto Nacional de Cardiología Ignacio ChávezMexico
  2. 2.Department of Immunology and RheumatologyInstituto Nacional de la Nutrición Salvador ZubiránTlalpanMéxico

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