Heart and Vessels

, Volume 9, Issue 5, pp 249–253

Long-term clinical effect of nilvadipine in patients with chronic heart failure: A double-blind placebo-controlled study

  • Masatsugu Hori
  • Hideyuki Sato
  • Michiko Karita
  • Kazuhisa Kodama
  • Noritake Hoki
  • Tohru Hayashi
  • Masashi Naka
  • Shinsuke Nanto
  • Yoshio Yamada
  • Takenobu Kamada
Originals

DOI: 10.1007/BF01745105

Cite this article as:
Hori, M., Sato, H., Karita, M. et al. Heart Vessels (1994) 9: 249. doi:10.1007/BF01745105

Summary

The long-term effect of calcium channel blockers on chronic heart failure is disappointing, probably because of reflex sympathetic activation through arterial vasodilation. However, nilvadipine may be beneficial for treatment of chronic heart failure since this drug has minimal effects on sympathetic activation. In this study, the effects of 12-week administration of nilvadipine or placebo on symptoms of heart failure and cardiac function were investigated in 23 patients with mild-to-moderate chronic heart failure in a double-blind trial. The patients were randomly assigned to either a nilvadipine group (16 mg daily) or a placebo group. Intergroup comparisons did not show significant differences in any parameters. Serious adverse effects were not observed during the study. Thus, this study failed to show any beneficial effect of nilvadipine in the long-term treatment of patients with chronic heart failure. We conclude that the long-term administration of nilvadipine (16 mg daily) is neither effective nor harmful in the treatment of patients with chronic heart failure.

Key words

Nilvadipine Chronic heart failure Long-term effects Calcium channel blocker 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Masatsugu Hori
    • 1
  • Hideyuki Sato
    • 1
  • Michiko Karita
    • 1
  • Kazuhisa Kodama
    • 1
  • Noritake Hoki
    • 1
  • Tohru Hayashi
    • 1
  • Masashi Naka
    • 1
  • Shinsuke Nanto
    • 1
  • Yoshio Yamada
    • 1
  • Takenobu Kamada
    • 1
  1. 1.First Department of MedicineOsaka University School of MedicineSuita, OsakaJapan

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