Heart and Vessels

, Volume 7, Supplement 1, pp 81–84 | Cite as

HLA Typing of Takayasu arteritis in Korea

  • Myoung Hee Park
  • Young Bae Park
Article

Summary

Takayasu arteritis occurs with a strong predilection for women and particular geographic areas, and as related to the etiology of the disease, association of HLA antigens has been suggested. In the present study, the authors investigated the association of Takayasu arteritis with class I and class II HLA antigens in 59 Korean patients with this disease.

Increased frequencies of HLA-Bw52 (χ2 6.213,P < 0.02), Cw6 (χ2 4.132,P < 0.05), DR7 (χ2 4.506,P < 0.04), and DQw2 (χ2 7.327,P < 0.01) were observed in the patient group as compared to the control group of healthy Koreans. In the Korean population, 2 risk factors in the HLA system for developing this disease appear to be (1) Bw52 and (2) DR7 and a probable haplotype ofCw6, B13, DR7, DQw2.

Previous studies of the Japanese population revealed association of Bw52 and class II HLA antigens (DR2, Dw12), which are in linkage disequilibrium with Bw52. It is of interest that in the Korean population, class II antigens (DR7, DQw2), which are not linked to BW52, are associated with the disease. This finding suggests that the disease susceptibility gene of Takayasu arteritis is located between theHLA-B locus andHLA-DR, DQ loci.

Key words

Takayasu arteritis HLA Korean 
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References

  1. 1.
    Committee Report (1975) Clinical and pathological studies of Takayasu's disease. A report by the Ministry of Health and Welfare, JapanGoogle Scholar
  2. 2.
    Lupi HE, Sánchez TG, Marcushamer J, Horwitz S, Vela JE (1977) Takayasu's arteritis, clinical study of 107 cases. Am Heart J 93:94–103Google Scholar
  3. 3.
    Ishikawa K (1978) Natural history and classification of occlusive thromboaortopathy (Takayasu's disease). Circulation 57:27–35PubMedGoogle Scholar
  4. 4.
    Committee Report (1968) Clinical and pathological studies of aortitis syndrome. Jpn Heart J 9:76–87Google Scholar
  5. 5.
    Isohisa I, Numano F, Maezawa H, Sasazuki T (1978) HLA-Bw52 in Takayasu disease. Tissue Antigens 12:246–248PubMedGoogle Scholar
  6. 6.
    Sasazuki T, Ohta N, Isohisa I, Numano F, Maezawa H (1979) Association between Takayasu disease and HLA-DHO. Tissue Antigens 14:177–178PubMedGoogle Scholar
  7. 7.
    Isohisa I, Numano F, Maezawa H, Sasazuki T (1982) Hereditary factors in Takayasu's disease. Angiology 33:98–104PubMedGoogle Scholar
  8. 8.
    Numano F, Ohta N, Sasazuki T (1982)HLA and clinical manifestations in Takayasu disease. Jpn Circ J 46:184–189PubMedGoogle Scholar
  9. 9.
    Moriuchi J, Wakisaka A, Aizawa M, Yasuda K, Yokota A, Tanabe T, Itakura K (1982)HLA-linked susceptibility gene of Takayasu disease. Hum Immunol 4:87–91PubMedGoogle Scholar
  10. 10.
    Reinsmoen NL, Sasazuki T, Kaneoka N, Ohta N, Noreen HJ, Greenberg LJ, Kersey JH (1978) Two distinct HLA-D specificities (DHO and Dw2) in linkage with HLA-DRw2 as defined in white and Japanese populations. Transplant Proc 10:789–791PubMedGoogle Scholar
  11. 11.
    Rose S, Mehra NK, Kumar R, Vaidya MC (1991) HLA-B5 and B21 antigens in aortoarteritis. Ind J Pediatr 58:85–89Google Scholar
  12. 12.
    Volkman DJ, Mann DL, Fauci AS (1982) Association between Takayasu's arteritis and a B-cell alloantigen in North Americans. New Engl J Med 306:464–465PubMedGoogle Scholar
  13. 13.
    Terasaki PI (1976) Microdroplet lymphocytotoxicity test. In: Ray JG, Hare DB, Pedersen PD (eds) Manual of tissue typing techniques. DHEW publication No. (NIH) 76–545, Bethesda. pp 69–80Google Scholar
  14. 14.
    WHO-HLA Nomenclature Committee (1989) Nomenclature for factors of theHLA system, 1987. Vox Sang 55:119–126Google Scholar
  15. 15.
    Numano F, Isohisa I, Maezawa H, Juji T (1979) HLA antigens in Takayasu's disease. Am Heart J 98:153–159PubMedGoogle Scholar
  16. 16.
    Takeuchi Y, Matsuki K, Saito Y, Sugimoto T, Juji T (1990)HLA-D region genomic polymorphism associated with Takayasu's arteritis. Angiology 41:421–426PubMedGoogle Scholar
  17. 17.
    Numano F, Isohisa I, Egami M, Ohta N, Sasazuki T (1983) HLA-DR MT and MB antigens in Takayasu disease. Tissue Antigens 21:208–212PubMedGoogle Scholar
  18. 18.
    Matsuki K, Maeda H, Juji T, Inoko H, Ando A, Tsuji K, Honda Y (1988) Taq I-generated HLA-DQ alpha polymorphism in Japanese patients with narcolepsy. Immunogenetics 27:87–90PubMedGoogle Scholar
  19. 19.
    Kim SJ, Nisperos B, Mickelson E, Choi IH, Dahlberg S, Kim JD, Giblett ER, Hansen JA (1986) TheHLA system in the Korean population. Hum Immunol 17:259–272PubMedGoogle Scholar
  20. 20.
    Aizawa M, Natori T, Wakisaka A, Konoda Y (1986)HLA in Asia-Oceania 1986. Hokkaido University Press, Sapporo, pp 1080–1103Google Scholar
  21. 21.
    Schreuder GMT, Doxiadis I, Parlevliet J, Gross-Wilde H (1984) HLA-DR, DQ, LB, and TA10 specificities of Ninth Workshop homozygous typing cells. In: Albert ED, Bauer MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg, pp 243–248Google Scholar
  22. 22.
    Bauer MP, Neugebauer M, Albert ED (1984) Reference tables of two-locus haplotype frequencies for all MHC marker loci. In: Albert ED, Bauer MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg, pp 677–678Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Myoung Hee Park
    • 1
  • Young Bae Park
    • 2
  1. 1.Department of Clinical PathologySeoul National University College of MedicineSeoulKorea
  2. 2.Department of Internal MedicineSeoul National University College of MedicineSeoulKorea

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