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Heart and Vessels

, Volume 7, Supplement 1, pp 18–25 | Cite as

Pathological features of the pulmonary artery in Takayasu arteritis

  • Osamu Matsubara
  • Nobuyuki Yoshimura
  • Atsuhisa Tamura
  • Tsutomu Kasuga
  • Ichirou Yamada
  • Fujio Numano
  • Eugene J. Mark
Article

Summary

Little attention has been paid to the pathological features of the pulmonary artery in Takayasu arteritis. Autopsy specimens of 6 cases of this disease were studied. Lesions were found in the aortic arch and its brachiocephalic branches in all cases and in both the aortic arch and thoracoabdominal aorta in 5 cases. The pathohistologic characters of the pulmonary artery were very similar to those of the systemic artery. Stenosis-recanalization, so-called blood vessels-in-blood vessels, of the pulmonary elastic arteries were found in four cases. These lesions were not observed in the systemic arteries, and most of the newly formed channels in them seemed to be branches of bronchial arteries. Luminal obstruction of pulmonary muscular arteries was observed in 4 cases, cellular arteritis of muscular arteries in 2 cases, and angiomatoid dilatation of small blood vessels in 2 cases. Thus in this study we found peculiar stenosis-recanalization lesions of the pulmonary elastic arteries, and also showed that the pulmonary elastic and muscular arteries are frequently involved in Takayasu arteritis. These findings suggest that pulmonary hypertension could influence morbidity and long-term mortality in this disease.

Key words

Takayasu arteritis (disease) Pulmonary artery Bronchial artery Pulmonary hypertension 

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References

  1. 1.
    Takayasu M (1908) Case with unusual changes of the central vessels in the retina (in Japanese). Acta Soc Ophthal Jpn 12:554–555Google Scholar
  2. 2.
    Nasu T (1962) Pathology of pulseless disease: Systemic study and critical review of 21 autopsy cases reported in Japan. Angiology 14:225–242Google Scholar
  3. 3.
    Ueda H (1968) Clinical and pathological studies of aortitis syndrome: Committee Report. Jpn Heart J 9:76–87PubMedGoogle Scholar
  4. 4.
    Oota K (1940) Ein seltener Fall von beiderseitigem Carotis-Subclaviaverschluss. Trans Soc Path Jpn 30:680–690Google Scholar
  5. 5.
    Lupi EH, Sanchez GT, Horwitz S, Gutierrez E (1975) Pulmonary artery involvement in Takayasu's arteritis. Chest 67:69–74PubMedGoogle Scholar
  6. 6.
    Sharma S, Kamalakar T, Rajani M, Talwar KK, Shrivastava S (1990) The incidence and patterns of pulmonary artery involvement in Takayasu's arteritis. Clin Radiol 42:177–181, 1990PubMedGoogle Scholar
  7. 7.
    Saito K (1988) Pulmonary arteritis in Takayasu's arteritis (in Japanese with English abstract). Jpn J Chest Dis 47:655–665Google Scholar
  8. 8.
    Nasu T (1975) Takayasu's truncoarteritis in Japan: A statistical observation of 76 autopsy cases. Pathol Microbiol 43:140–146Google Scholar
  9. 9.
    Nagata S (1990) Present sate of autopsy cases of Takayasu's arteritis (aortitis syndrome) in Japan (in Japanese with English abstract). Myakkanngaku 30:1303–1308Google Scholar
  10. 10.
    Nagata S, Abe F, Hotchi M (1990) A histopathological study on the marginal lesions in Takayasu's arteritis (in Japanese with English abstract). Myakkangaku 30:1367–1370Google Scholar
  11. 11.
    Ishikawa T (1977) Systemic artery-pulmonary artery communication in Takayasu's arteritis. Am J Radiol 128:389–393Google Scholar
  12. 12.
    Yamada I, Shibuya H, Matsubara O, Umehara I, Makino T, Numano F, Suzuki S (to be published) Pulmonary artery disease in Takayasu arteritis: Angiographic findings. Am J RadiolGoogle Scholar
  13. 13.
    Hayashi K, Nagasaki M, Matsunaga N, Hombo Z, Imamura T (1986) Initial pulmonary artery involvement in Takayasu arteritis. Radiology 159:401–403PubMedGoogle Scholar
  14. 14.
    Fujioka T, Tanaka K, Yamaguchi I, Takahashi S, Kubokura T, Kimata S, Sekiguchi M, Kondo M, Shibuya M, Hirosawa K (1984) Clinical findings and prognosis of aortitis syndrome associated with pulmonary vascular disease (in Japanese with English abstract). Kokyu to Junkan 32:723–728PubMedGoogle Scholar
  15. 15.
    Haas A, Stihm ER (1986) Takayasu's arteritis presenting as pulmonary hypertension. Am J Dis Child 140:372–374PubMedGoogle Scholar
  16. 16.
    Chauvaud S, Mace L, Brunewald P, Tricot JL, Camilleri JP, Carpentier A (1987) Takayasu's arteritis with bilateral pulmonary artery stenosis. Successful surgical correction. J Thorac Cardiovasc Surg 94:246–250PubMedGoogle Scholar
  17. 17.
    Hokamura Y, Uchida H, Shouno H, Takenaka S, Shima K, Takeguchi T, Nagao K, Hayakawa H (1988) A case of aortitis syndrome associated with primary pulmonary hypertension (in Japanese with English abstract). Kokyu to Junkan 36:899–903PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Osamu Matsubara
    • 1
  • Nobuyuki Yoshimura
    • 1
  • Atsuhisa Tamura
    • 1
  • Tsutomu Kasuga
    • 1
  • Ichirou Yamada
    • 2
  • Fujio Numano
    • 3
  • Eugene J. Mark
    • 4
  1. 1.Department of PathologyFaculty of Medicine, Tokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of RadiologyFaculty of Medicine, Tokyo Medical and Dental UniversityTokyoJapan
  3. 3.Department of Internal MedicineFaculty of Medicine, Tokyo Medical and Dental UniversityTokyoJapan
  4. 4.Department of PathologyMassachusetts General HospitalBostonUSA

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