European Journal of Clinical Pharmacology

, Volume 43, Issue 2, pp 121–124 | Cite as

Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times

Use in studying the actions of cisapride in diabetic patients
  • J. F. Bergmann
  • O. Chassany
  • P. J. Guillausseau
  • M. Bayle
  • S. Chagnon
  • C. Caulin
  • J. R. Sallenave


The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design.

It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.

Key words

Cisapride Diabetic neuropathy gastric emptying orocaecal transit time gastroparesis controlled trial 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yang R, Arem R, Chan L (1984) Gastrointestinal tract complications of diabetes mellitus. Pathophysiology and management. Arch Intern Med 144: 1251–1256PubMedGoogle Scholar
  2. 2.
    Ewing DJ, Clarke BF (1986) Diabetic autonomic neuropathy: present insights and future prospects. Diabetes Care 9: 648–665PubMedGoogle Scholar
  3. 3.
    Feldman M, Schiller LR (1983) Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 98: 378–384PubMedGoogle Scholar
  4. 4.
    Buysschaert M, Moulart M, Urbain JL, Pauwells S, De Roy L, Ketelslegers JM, Lambert A (1987) Impaired gastric emptying in diabetic patients with cardiac autonomic neuropathy. Diabetes Care 10: 448–452PubMedGoogle Scholar
  5. 5.
    Campbell IW, Heading RC, Tothill P, Buist TA, Ewing DJ, Clarke BF (1977) Gastric emptying in diabetic autonomic neuropathy. Gut 18: 462–467PubMedGoogle Scholar
  6. 6.
    Snape WJ, Battle WM, Schwartz sulphasalazine-sulphapyridine, Braunstein SN, Goldstein HA, Alavi A (1982) Metoclopramide to treat gastroparesis due to diabetes mellitus. Ann Intern Med 96: 444–446PubMedGoogle Scholar
  7. 7.
    McCallum RW, Prakash C, Campoli-Richards DM, Goa KL (1988) Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 36: 652–681PubMedGoogle Scholar
  8. 8.
    Arhan P, Devroede G, Jehannin B, Lanza M, Faverdin C, Dornic C, Persoz B, Tétreault L, Perey B, Pellerin D (1981) Segmental colonic transit time. Dis Colon Rectum 24: 625–629PubMedGoogle Scholar
  9. 9.
    Chaussade S, Roche H, Khyari A, Couturier D, Guerre J (1986) Mesure du temps de transit colique (TTC): description et validation d'une nouvelle technique. Gastroenterol Clin Biol 10: 385–389PubMedGoogle Scholar
  10. 10.
    Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG (1987) Simplified assessment of segmental colonic transit. Gastroenterology 92: 40–47Google Scholar
  11. 11.
    Feldman M, Smith HJ, Simon TR (1984) Gastric emptying of solid radio-opaque markers: studies in healthy subjects and diabetic patients. Gastroenterology 87: 895–902PubMedGoogle Scholar
  12. 12.
    Bertrand J, Metman EH, Danquechin Dorval E, Rouleau P, D'Hueppe A, Itti R, Philippe L (1980) Etude du temps d'évacuation gastrique de repas normaux au moyen de granules radioopaques. Applications cliniques et validation. Gastroenterol Clin Biol 4: 770–776PubMedGoogle Scholar
  13. 13.
    Siegel JA, Urbain JL, Adler LP, Charkes ND, Maurer AH, Krevski B, Knight LC, Fischer RS, Malmud LS (1988) Biphasic nature of gastric emptying. Gut 29: 85–89PubMedGoogle Scholar
  14. 14.
    Feldman M, Smith HJ (1987) Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo. Gastroenterology 92: 171–174PubMedGoogle Scholar
  15. 15.
    Isal JP, Dahan R, Bergmann JF, Caulin C (1985) Parallel evolution of gastric emptying and severity of the disease in diabetics. Gastroenterology 85: 1427Google Scholar
  16. 16.
    Staniforth DH (1987) Effect of drugs on oro-caecal transit time assessed by the lactulose/breath hydrogen method. Eur J Clin Pharmacol 33: 55–58PubMedGoogle Scholar
  17. 17.
    Staniforth DH (1989) Comparison of orocaecal transit times assessed by the lactulose/breath hydrogen and the sulphasalazine/sulphapyridine methods. Gut 30: 978–982PubMedGoogle Scholar
  18. 18.
    Kellow JE, Borody TJ, Phillips SF, Haddad AC, Brown ML (1986) Sulphapyridine appearance in plasma after salicylazosulfapyridine. Gastroenterology 91: 396–400PubMedGoogle Scholar
  19. 19.
    Read NW, Houghton LA (1989) Physiology of gastric emptying and pathophysiology of gastroparesis. Gastroenterol Clin North Amer 18: 359–373Google Scholar
  20. 20.
    Isal JP (1987) Gastric evacuation of a dyspeptogenic meal. Effect of cisapride. Progr Med 43 (Suppl 1): 57–60Google Scholar
  21. 21.
    Tympner F (1987) Ultrasonographic study of the effect of gastrokinetic drugs on gastric emptying time. Progr Med 43 [Suppl 1]: 51–55Google Scholar
  22. 22.
    Urbain JL, Siegel JA, Debie NC, Pauwels SP (1988) Effect of cisapride on gastric emptying in dyspeptic patients. Dig Dis Sci 33: 779–783PubMedGoogle Scholar
  23. 23.
    Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernier JJ (1985) Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride). Gut 26: 352–358PubMedGoogle Scholar
  24. 24.
    Corinaldesi R, Stanghellini V, Raiti C, Rea E, Salgemini R, Barbara L (1987) Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut 28: 300–305PubMedGoogle Scholar
  25. 25.
    Brogna A, Ferrara R, Scornavacca G, Lombardo A, Bucceri A, Catalano F, Paradisi V, Onorato S (1989) Cisapride and gastric emptying of a solid meal in dyspeptic diabetics without autonomic neuropathy and in healthy volunteers. Eur J Clin Pharmacol 37: 411–413PubMedGoogle Scholar
  26. 26.
    Horowitz M, Maddox A, Harding PE, Maddern GJ, Chatterton BE, Wishart J, Shearman JC (1987) Effect of cisapride on gastric and oesophageal emptying in insulin-dependent diabetes mellitus. Gastroenterology 92: 1899–1907PubMedGoogle Scholar
  27. 27.
    Edwards CA, Holden S, Brown C, Read NW (1987) Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 28: 13–16PubMedGoogle Scholar
  28. 28.
    Bigard MA, Durivaux B, Fraitag B (1988) Action du cisapride sur le temps de transit oro-caecal d'un repas dyspeptogène chez le sujet sain. Gastroenterol Clin Biol 12: 75–76PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. F. Bergmann
    • 1
  • O. Chassany
    • 1
  • P. J. Guillausseau
    • 2
  • M. Bayle
    • 3
  • S. Chagnon
    • 4
  • C. Caulin
    • 1
  • J. R. Sallenave
    • 5
  1. 1.Unité de Recherches ThérapeutiquesHôpital LariboisièreParisFrance
  2. 2.Department of EndocrinologyLariboisière HospitalParisFrance
  3. 3.Department of PharmacyLariboisière HospitalParisFrance
  4. 4.Department of RadiologyLariboisière HospitalParisFrance
  5. 5.Janssen LaboratoriesBoulogne BillancourtFrance

Personalised recommendations