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The enzymology of myelination

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Summary

We have presented a résumé of recent investigations of the biochemistry of glycolipids and glycoproteins in the developing nervous system. The novel observations and advances in these areas coupled with relevant studies on the metabolism of myelin basic protein provide a basis for the development of a hypothesis regarding the formation of the myelin sheath which is outlined in this communication.

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References

  1. [1]

    R. O. Brady, J. Biol. Chem. 235, 3099–3103 (1960).

  2. [2]

    R. Fumagalli, M. E. Smith, G. Urna and R. Paoletti, J. Neurochem. 16, 1329–1339 (1969).

  3. [3]

    A. N. Davidson, Handbook of Neurochemistry (Lajtha, A., ed.) Vol. 3, pp. 547–560, Plenum, New York (1970).

  4. [4]

    W. C. McMurray, K. P. Strickland, J. F. Berry and R. J. Rossiter, Biochem. J. 66, 634–644 (1957).

  5. [5]

    R. O. Brady, and G. J. Koval, J. Biol. Chem. 233, 26–31 (1958).

  6. [6]

    N. S. Radin, F. B. Martin and J. R. Brown, J. Biol. Chem. 224, 499–507 (1957).

  7. [7]

    R. M. Burton, M. A. Sodd and R. O. Brady, J. Biol. Chem. 233, 1053–1060 (1958).

  8. [8]

    N. S. Radin, Handbook of Neurochemistry (Lajtha, A., ed.) Vol. 3, pp. 415–424, Plenum, New York (1970).

  9. [9]

    A. N. Davison, Current trends in the biochemistry of lipids (Ganguly, J., and Smellie, R. M. S., eds.) pp. 129–139, Academic Press, London (1972).

  10. [10]

    L. Svennerholm, Biochem. Biophys. Res. Commun. 9, 436–446 (1962).

  11. [11]

    E. H. Kolodny, R. O. Brady and B.W. Volk, Biochem. Biophys. Res. Commun. 37, 526–631 (1969).

  12. [12]

    J. F. Tallman, W. G. Johnson and R. O. Brady, J. Clin. Invest. 51, 2339–2345 (1972).

  13. [13]

    H. Seifert and G. Uhlenbruck, Die Naturwissenschaften 8, 190 (1965).

  14. [14]

    D. Kostic and F. Buchheit, Life Sciences 9, 589–596 (1970).

  15. [15]

    P. T. Mora, R. O. Brady, R. M. Bradley and V. W. McFarland, Proc. Nat. Acad. Sci. USA 63, 1290–296 (1969).

  16. [16]

    R. Q. Brady and P. T. Mora (1970) Biochim. Biophys. Acta 218, 308–319.

  17. [17]

    B. Kaufman, S. Basu and S. Roseman, J. Biol. Chem. 243, 5802–5804 (1968).

  18. [18]

    S. Roseman, Chem. Phys. Lipids 5, 270–297 (1970).

  19. [19]

    F. A. Cumar, P. H. Fishman and R. O. Brady, J. Biol. Chem. 246, 5075–5084 (1971).

  20. [20]

    F. A. Cumar, J. F. Tallman and R. O. Brady, J. Biol. Chem. 247, 2322–2327 (1972).

  21. [21]

    K. Suzuki, J. Neurochem. 14, 917–925 (1967).

  22. [22]

    L. Svennerholm, Handbook of Neurochemistry (Lajtha, A., ed.) Vol. 3, pp. 425–452, Plenum, New York (1970).

  23. [23]

    H.-D. Klenk and P. W. Choppin, Proc. Nat. Acad. Sci. USA 66, 57–64 (1970).

  24. [24]

    O. Renkonen, C. G. Gahmberg and L. Kaarianinen, Acta Chem. Scand. 24, 733–735 (1970).

  25. [25]

    P. del Rio-Hortega, Mem. Rel. Soc. Espan. Hist. Nat. 14, 5 (1928).

  26. [26]

    B. B. Geren, Exptl. Cell Res. 7, 558–562 (1954).

  27. [27]

    A. N. Davison and A. Peters, Myelination, pp. 1–238, Charles C. Thomas, Springfield, Ill. (1970).

  28. [28]

    K. Suzuki, S. E. Poduslo and W. T. Norton, Biochim. Biophys. Acta 144, 375–381 (1967).

  29. [29]

    R. K. Yu, R. W. Ledeen and L. F. Eng, Trans. Amer. Soc. Neurochem. 4, 97 (1973).

  30. [30]

    L. A. Horrocks, R. J. Meckler and R. L. Collins, Variations in chemical composition of the nervous system (G. B. Ansell, ed.) p. 46, Pergamon Press, Oxford (1966).

  31. [31]

    M. L. Cuzner and A. N. Davison, Biochem. J. 106, 29–34 (1968).

  32. [32]

    H. C. Agrawal, N. L. Banik, A. H. Bone, A. N. Davison, R. F. Mitchell and M. Spohn, Biochem. J. 120, 635–642 (1970).

  33. [33]

    R. H. Quarles, J. L. Everly and R. O. Brady, Biochem. Biophys. Res. Commun. 47, 491–497 (1972).

  34. [34]

    R. H. Quarles, J. L. Everly and R. O. Brady, J. Neurochem. in press (1973).

  35. [35]

    M. Zatz and S. H. Barondes, J. Neurochem. 17, 157–163 (1970).

  36. [36]

    R. H. Quarles and R. O. Brady, J. Neurochem. 18, 1809–1820 (1971).

  37. [37]

    J.-M. Matthieu, R. O. Brady and R. H. Quarles, Trans. Amer. Soc. Neurochem. 4, 124 (1973).

  38. [38]

    R. H. Quarles, J. L. Everly and R. O. Brady, Brain Res., in press (1973).

  39. [39]

    N. Baumann, C. Jacque, S. Pollet and M. L. Harpin, Eur. J. Biochem. 4, 340–344 (1968).

  40. [40]

    N. M. Neskovic, L. L. Sarlieve and P. Mandel, Brain Res. 42, 147–157 (1972).

  41. [41]

    J.-M. Matthieu, U. Schneider and N. Herschkowitz, Brain Res. 42, 433–439 (1972).

  42. [42]

    J.-M. Matthieu, R. O. Brady and R. H. Quarles, J. Neurochem. manuscript submitted (1973).

  43. [43]

    S. Greenfield, W. T. Norton and P. Morell, J. Neurochem. 18, 2119–2128 (1971).

  44. [44]

    H. J. Frey, P. J. Riekkinen, A. U. Arstila, T. Pelliniemi and U. K. Rinne, Brain Res. 45, 165–173 (1972).

  45. [45]

    R. Sammeck and R. O. Brady, Brain Res. 42, 441–453 (1972).

  46. [46]

    R. H. Laatsch, M. W. Kies, S. Gordon and E. C. Alvord Jr., J. Exp. Med. 115, 777–788 (1962).

  47. [47]

    L. F. Eng, F. C. Chao, B. Gerstl, D. Pratt and M. G. Tataststjerna, Biochemistry 7, 4455–4465 (1968).

  48. [48]

    J. A. Benjamins and G. M. McKhann, Basic Neurochemistry (R. W. Albers, G. J. Siegel, R. Katzman and B. W. Agranoff, eds.) pp. 269–298 (1972). Little, Brown and Co., Boston

  49. [49]

    R. Sammeck, R. E. Martensson and R. O. Brady, Brain Res. 34, 241–254 (1971).

  50. [50]

    A. Hagopian, F. C. Westfall, J. S. Whitehead and E. H. Eylar, J. Biol. Chem. 246, 2519–2523 (1971).

  51. [51]

    G. K. W. Ko and E. Raghupathy, Biochim. Biophys. Acta 264, 129–143 (1972).

  52. [52]

    E. H. Eylar, Multiple Sclerosis (E. J. Field, T. M. Bell and P. R. Carnegie, eds.) pp. 90–104, North Holland, Amsterdam (1972).

  53. [53]

    G. Dawson, S. F. Kemp, A. C. Stoolmiller and A. Dorfman, Biochem. Biophys. Res. Commun. 44, 687–694 (1971).

  54. [54]

    R. O. Brady, P. H. Fishman and P. T. Mora, Federation Proc. 32, 102–108 (1973).

  55. [55]

    R. A. Cumar, R. O. Brady, E. H. Kolodny, V. W. McFarland and P. T. Mora, Proc. Nat. Acad. Sci. USA 67, 757–764 (1970).

  56. [56]

    E. W. Sutherland, T. W. Rall and T. Menon, J. Biol. Chem. 237, 1220–1227 (1962).

  57. [57]

    G. H. DeVries, W. T. Norton and C. S. Raine, Science 175, 1370–1372 (1972).

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Brady, R.O., Quarles, R.H. The enzymology of myelination. Mol Cell Biochem 2, 23–29 (1973). https://doi.org/10.1007/BF01738675

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Keywords

  • Nervous System
  • Relevant Study
  • Myelin Basic Protein
  • Basic Protein
  • Myelin Sheath