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Basic fibroblast growth factor and its relation to angiogenesis in normal and neoplastic tissue

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Summary

Basic fibroblast growth factor is a protein widely distributed in the organism. It can stimulate the proliferation and differentiation of many cells and it is extremely potent in inducing angiogenesis, the formation of new blood vessels. In this article, some of its structural and biological properties are reviewed. In particular, the possible implications of basis fibroblast growth factor in normal and tumor angiogenesis are considered.

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Abbreviations

bFGF:

basic fibroblast growth factor

kb:

kilobases

Mr:

relative molecular weight

pI:

isoelectric point

TAF:

tumor angiogenesis factor

References

  1. 1.

    Abraham JA, Mergia A, Whang JL, Tumolo A, Friedman J, Hjerrild KA, Gospodarowicz D, Fiddes JC (1986) Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science 233:545–548

  2. 2.

    Abraham JA, Whang JL, Tumolo A, Fiddes JC (1986) Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells. Cold Spring Harbor Symp Quant Biol LI:657–668

  3. 3.

    Baird A, Mormede P, Böhlen P (1985) Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor. Biochem Biophys Res Commun 126:358–364

  4. 4.

    Collins T, Bonthron DT, Orkin SH (1987) Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. Nature 328:621–624

  5. 5.

    Delli Bovi P, Curatola AM, Kern FG, Greco A, Ittman M, Basilico C (1987) An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell 50:729–737

  6. 6.

    DiBlasio AM, Schweigerer L, Ferrara N, Gospodarowicz D, Jaffe RB (1987) Isolation of basic fibroblast growth factor from the human fetal adrenal gland during the second trimester. Endocrinology (in press)

  7. 7.

    Dickson C, Peters G (1987) Potential oncogene product related to growth factors. Nature 326:833

  8. 8.

    Esch F, Baird A, Ling N, Ueno N, Hill F, Denoroy L, Klepper R, Gospodarowicz D, Böhlen P, Guillemin R (1985) Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc Natl Acad Sci USA 82:6507–6511

  9. 9.

    Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D (1987) Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci USA 84:5773–5777

  10. 10.

    Folkman J (1985) Tumor angiogenesis. Adv Cancer Res 43:175–203

  11. 11.

    Folkman J, Klagsburn M (1987) Angiogenic factors. Science 235:442–447

  12. 12.

    Gimenez-Gallego G, Rodkey J, Bennett C, Rios-Candelore M, DiSalvo J, Thomas K (1985) Brain-derived acidic fibroblast growth factor: Complete amino acid sequence and homologies. Science 230:1385–1388

  13. 13.

    Gospodarowicz D (1974) Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 249:123–127

  14. 14.

    Gospodarowicz D, Mescher AL (1981) Fibroblast growth factor and vertebrate regeneration. In: Riccardi VM, Mulvihill JJ (eds) Adv Neurol 29:149–171

  15. 15.

    Gospodarowicz D, Cheng J, Lui G-M, Baird A, Böhlen P (1984) Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: Identity with pituitary fibroblast growth factor. Proc Natl Acad Sci USA 81:6963–6967

  16. 16.

    Gospodarowicz D, Neufeld G, Schweigerer L (1986) Fibroblast growth factor. Mol Cell Endocrinol 46:187–204

  17. 17.

    Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G (1987) Structural characterization and biological functions of fibroblast growth factor. Endocrine Rev 8:95–114

  18. 18.

    Klagsbrun M, Sasse J, Sullivan R, Smith JA (1986) Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. Proc Natl Acad Sci USA 83:2448–2452

  19. 19.

    Klagsbrun M, Smith S, Sullivan R, Shing Y, Davidson S, Smith JA, Sasse J (1987) Multiple forms of basic fibroblast growth factor: Amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases. Proc Natl Acad Sci USA 84:1839–1843

  20. 20.

    Marx JL (1987) New family of growth factor genes identified. Science 237:602–603

  21. 21.

    Mergia A, Eddy R, Abraham JA, Fiddes JC, Shows TB (1986) The genes for basic and acidic fibroblast growth factors are on different human chromosomes. Biochem Biophys Res Commun 138:644–651

  22. 22.

    Moenner M, Chevallier B, Badet J, Barritault D (1986) Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells. Proc Natl Acad Sci USA 83:5024–5028

  23. 23.

    Moscatelli D, Presta M, Joseph-Silverstein J, Rifkin DB (1986) Both normal and tumor cells produce basic fibroblast growth factor. J Cell Physiol 129:273–276

  24. 24.

    Neufeld G, Gospodarowicz D (1985) The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells. J Biol Chem 260:13860–13868

  25. 25.

    Neufeld G, Ferrara N, Schweigerer L, Mitchell R, Gospodarowicz D (1987) Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121:597–603

  26. 26.

    Olwin BB, Hauschka SD (1986) Identification of the fibroblast growth factor receptor of swiss 3T3 cells and mouse skeletal muscle myoblasts. Biochemistry 25:3487–3492

  27. 27.

    Pettmann B, Labourdette G, Weibel M, Sensenbrenner M (1986) The brain fibroblast growth factor (FGF) is localized in neurons. Neurosci Lett 68:175–180

  28. 28.

    Risau W (1986) Developing brain produces an angiogenesis factor. Proc Natl Acad Sci USA 83:3855–3859

  29. 29.

    Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325:257–259

  30. 30.

    Schweigerer L, Neufeld G, Mergia A, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Basic fibroblast growth factor in human rhabdomyosarcoma cells: Implications for the proliferation and neovascularization of myoblast-derived tumors. Proc Natl Acad Sci USA 84:842–846

  31. 31.

    Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Basic fibroblast growth factor: Production and growth stimulation in cultured adrenal cortex cells. Endocrinology 120:796–800

  32. 32.

    Schweigerer L, Malerstein B, Neufeld G, Gospodarowicz D (1987) Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells. Biochem Biophys Res Commun 143:934–940

  33. 33.

    Schweigerer L, Neufeld G, Gospodarowicz D (1987) Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells. J Clin Invest 80:1516–1520

  34. 34.

    Schweigerer L, Ferrara N, Neufeld G, Gospodarowicz D (1988) Basic fibroblast growth factor: Expression in cultured cells derived from corneal endothelium and lens epithelium. Exptl Eye Res (in press)

  35. 35.

    Schwab M (1987) Amplification of cellular oncogenes during evolution of tumor cells. In: Zur Hausen H, Schlehofer J (eds) The role of amplification in tumor initiation and promotion

  36. 36.

    Seeburg PH, Colby WW, Capon DJ, Goeddel DV, Levinson AD (1984) Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 312:71–75

  37. 37.

    Shing Y, Folkman J, Sullivan R, Butterfield C, Murray J, Klagsbrun M (1984) Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor. Science 223:1296–1299

  38. 38.

    Slack JMW, Darlington BG, Heath JK, Godsave SF (1987) Heparin binding growth factors as agents of mesoderm induction. Nature 326:197–199

  39. 39.

    Sporn MB, Roberts AB (1987) Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 78:329–332

  40. 40.

    Taira M, Yoshida T, Miyagawa K, Sakamoto H, Terada M, Sugimura T (1987) cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci USA 84:2980–2984

  41. 41.

    Virchow R (1886) Die krankhaften Geschwülste. Hirschwald, Berlin

  42. 42.

    Vlodavsky I, Folkman J, Sullivan R, Fridman R, Ishai-Michaeli R, Sasse J, Klagsbrun M (1987) Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci USA 84:2292–2296

  43. 43.

    Weiss L (1985) Principles of metastasis. 1st edn. Academic Press, Orlando

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Schweigerer, L. Basic fibroblast growth factor and its relation to angiogenesis in normal and neoplastic tissue. Klin Wochenschr 66, 340–345 (1988). https://doi.org/10.1007/BF01735791

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Key words

  • Neovascularization
  • Tumor angiogenesis