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On the origins of tandemly repeated genes: Does histone gene copy number inDrosophila reflect chromosomal location?

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Widely regarded beliefs aboutDrosophila histone gene copy numbers and developmental requirements have been generalized from fairly limited data since studies on histone gene arrangements and copy numbers have been largely confined to a single species,D. melanogaster. Histone gene copy numbers and chromosomal locations were examined in three species:D. melanogaster, D. hydei andD. hawaiiensis. Quantitative whole genome blot analysis of DNA from diploid tissues revealed a tenfold variability in histone gene copy numbers for these three species. In situ hybridization to polytene chromosomes showed that the histone DNA (hDNA) chromosomal location is different in all three species. These observations lead us to propose a relationship between histone gene reiteration and chromosomal position.

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Correspondence to Linda D. Strausbaugh.

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Fitch, D.H.A., Strausbaugh, L.D. & Barrett, V. On the origins of tandemly repeated genes: Does histone gene copy number inDrosophila reflect chromosomal location?. Chromosoma 99, 118–124 (1990). https://doi.org/10.1007/BF01735327

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  • Blot Analysis
  • Developmental Biology
  • Gene Copy
  • Single Species
  • Chromosomal Location